Fehringer, Gordon, Kraft, Peter
ORCID: 0000-0002-4472-8103, Pharoah, Paul D., Eeles, Rosalind A., Chatterjee, Nilanjan, Schumacher, Fredrick R., Schildkraut, Joellen M., Lindstrom, Sara, Brennan, Paul, Bickeboller, Heike
ORCID: 0000-0002-3361-5488, Houlston, Richard S., Landi, Maria Teresa, Caporaso, Neil, Risch, Angela
ORCID: 0000-0002-8026-5505, Al Olama, Ali Amin, Berndt, Sonja I., Giovannucci, Edward L., Gronberg, Henrik, Kote-Jarai, Zsofia, Ma, Jing, Muir, Kenneth, Stampfer, Meir J., Stevens, Victoria L., Wiklund, Fredrik, Willett, Walter C., Goode, Ellen L., Permuth, Jennifer B., Risch, Harvey A., Reid, Brett M., Bezieau, Stephane, Brenner, Hermann
ORCID: 0000-0002-6129-1572, Chan, Andrew T., Chang-Claude, Jenny, Hudson, Thomas J., Kocarnik, Jonathan K., Newcomb, Polly A., Schoen, Robert E., Slattery, Martha L., White, Emily, Adank, Muriel A., Ahsan, Habibul, Aittomaki, Kristiina, Baglietto, Laura
ORCID: 0000-0002-8193-7529, Blomquist, Carl, Canzian, Federico
ORCID: 0000-0002-4261-4583, Czene, Kamila, dos-Santos-Silva, Isabel, Eliassen, A. Heather, Figueroa, Jonine D., Flesch-Janys, Dieter, Fletcher, Olivia
ORCID: 0000-0001-9387-7116, Garcia-Closas, Montserrat, Gaudet, Mia M., Johnson, Nichola, Hall, Per, Hazra, Aditi, Hein, Rebecca, Hofman, Albert, Hopper, John L., Irwanto, Astrid, Johansson, Mattias
ORCID: 0000-0002-3116-5081, Kaaks, Rudolf, Kibriya, Muhammad G., Lichtner, Peter, Liu, Jianjun
ORCID: 0000-0002-3255-3019, Lund, Eiliv, Makalic, Enes, Meindl, Alfons, Muller-Myhsok, Bertram, Muranen, Taru A., Nevanlinna, Heli, Peeters, Petra H., Peto, Julian, Prentice, Ross L., Rahman, Nazneen, Sanchez, Maria Jose, Schmidt, Daniel F., Schmutzler, Rita K., Southey, Melissa C., Tamimi, Rulla, Travis, Ruth C., Turnbull, Clare, Uitterlinden, Andre G., Wang, Zhaoming
ORCID: 0000-0001-7556-3869, Whittemore, Alice S., Yang, Xiaohong R., Zheng, Wei
ORCID: 0000-0003-1226-070X, Buchanan, Daniel D., Casey, Graham, Conti, David V., Edlund, Christopher K., Gallinger, Steven, Haile, Robert W., Jenkins, Mark
ORCID: 0000-0002-8964-6160, Le Marchand, Loic, Li, Li, Lindor, Noralene M., Schmit, Stephanie L.
ORCID: 0000-0001-5931-1194, Thibodeau, Stephen N., Woods, Michael O., Rafnar, Thorunn, Gudmundsson, Julius, Stacey, Simon N., Stefansson, Kari, Sulem, Patrick, Chen, Y. Ann, Tyrer, Jonathan P., Christiani, David C., Wei, Yongyue, Shen, Hongbing
ORCID: 0000-0002-2581-5906, Hu, Zhibin, Shu, Xiao-Ou, Shiraishi, Kouya, Takahashi, Atsushi, Bosse, Yohan, Obeidat, Ma'en, Nickle, David, Timens, Wim
ORCID: 0000-0002-4146-6363, Freedman, Matthew L., Li, Qiyuan, Seminara, Daniela, Chanock, Stephen J., Gong, Jian, Peters, Ulrike, Gruber, Stephen B., Amos, Christopher I., Sellers, Thomas A., Easton, Douglas F., Hunter, David J., Haiman, Christopher A., Henderson, Brian E. and Hung, Rayjean J.
(2016).
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
Cancer Res., 76 (17).
S. 5103 - 5115.
PHILADELPHIA:
AMER ASSOC CANCER RESEARCH.
ISSN 1538-7445
Full text not available from this repository.
Abstract
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus atCDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. (C) 2016 AACR.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Fehringer, Gordon | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kraft, Peter | UNSPECIFIED | orcid.org/0000-0002-4472-8103 | UNSPECIFIED | Pharoah, Paul D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eeles, Rosalind A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chatterjee, Nilanjan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schumacher, Fredrick R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schildkraut, Joellen M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lindstrom, Sara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brennan, Paul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bickeboller, Heike | UNSPECIFIED | orcid.org/0000-0002-3361-5488 | UNSPECIFIED | Houlston, Richard S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Landi, Maria Teresa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Caporaso, Neil | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Risch, Angela | UNSPECIFIED | orcid.org/0000-0002-8026-5505 | UNSPECIFIED | Al Olama, Ali Amin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Berndt, Sonja I. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giovannucci, Edward L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gronberg, Henrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kote-Jarai, Zsofia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ma, Jing | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muir, Kenneth | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stampfer, Meir J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stevens, Victoria L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wiklund, Fredrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Willett, Walter C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Goode, Ellen L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Permuth, Jennifer B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Risch, Harvey A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Reid, Brett M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bezieau, Stephane | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brenner, Hermann | UNSPECIFIED | orcid.org/0000-0002-6129-1572 | UNSPECIFIED | Chan, Andrew T. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang-Claude, Jenny | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hudson, Thomas J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kocarnik, Jonathan K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Newcomb, Polly A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schoen, Robert E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Slattery, Martha L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | White, Emily | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Adank, Muriel A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ahsan, Habibul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Aittomaki, Kristiina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Baglietto, Laura | UNSPECIFIED | orcid.org/0000-0002-8193-7529 | UNSPECIFIED | Blomquist, Carl | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Canzian, Federico | UNSPECIFIED | orcid.org/0000-0002-4261-4583 | UNSPECIFIED | Czene, Kamila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | dos-Santos-Silva, Isabel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eliassen, A. Heather | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Figueroa, Jonine D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Flesch-Janys, Dieter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fletcher, Olivia | UNSPECIFIED | orcid.org/0000-0001-9387-7116 | UNSPECIFIED | Garcia-Closas, Montserrat | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gaudet, Mia M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Johnson, Nichola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hall, Per | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hazra, Aditi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hein, Rebecca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hofman, Albert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hopper, John L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Irwanto, Astrid | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Johansson, Mattias | UNSPECIFIED | orcid.org/0000-0002-3116-5081 | UNSPECIFIED | Kaaks, Rudolf | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kibriya, Muhammad G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lichtner, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Liu, Jianjun | UNSPECIFIED | orcid.org/0000-0002-3255-3019 | UNSPECIFIED | Lund, Eiliv | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Makalic, Enes | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meindl, Alfons | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muller-Myhsok, Bertram | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muranen, Taru A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nevanlinna, Heli | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peeters, Petra H. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peto, Julian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Prentice, Ross L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rahman, Nazneen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sanchez, Maria Jose | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmidt, Daniel F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmutzler, Rita K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Southey, Melissa C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tamimi, Rulla | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Travis, Ruth C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Turnbull, Clare | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Uitterlinden, Andre G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Zhaoming | UNSPECIFIED | orcid.org/0000-0001-7556-3869 | UNSPECIFIED | Whittemore, Alice S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yang, Xiaohong R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zheng, Wei | UNSPECIFIED | orcid.org/0000-0003-1226-070X | UNSPECIFIED | Buchanan, Daniel D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Casey, Graham | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Conti, David V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Edlund, Christopher K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gallinger, Steven | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Haile, Robert W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jenkins, Mark | UNSPECIFIED | orcid.org/0000-0002-8964-6160 | UNSPECIFIED | Le Marchand, Loic | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Li, Li | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lindor, Noralene M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmit, Stephanie L. | UNSPECIFIED | orcid.org/0000-0001-5931-1194 | UNSPECIFIED | Thibodeau, Stephen N. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Woods, Michael O. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rafnar, Thorunn | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gudmundsson, Julius | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stacey, Simon N. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stefansson, Kari | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sulem, Patrick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chen, Y. Ann | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tyrer, Jonathan P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Christiani, David C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wei, Yongyue | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shen, Hongbing | UNSPECIFIED | orcid.org/0000-0002-2581-5906 | UNSPECIFIED | Hu, Zhibin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shu, Xiao-Ou | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shiraishi, Kouya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Takahashi, Atsushi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bosse, Yohan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Obeidat, Ma'en | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nickle, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Timens, Wim | UNSPECIFIED | orcid.org/0000-0002-4146-6363 | UNSPECIFIED | Freedman, Matthew L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Li, Qiyuan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Seminara, Daniela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chanock, Stephen J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gong, Jian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peters, Ulrike | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gruber, Stephen B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Amos, Christopher I. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sellers, Thomas A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Easton, Douglas F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hunter, David J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Haiman, Christopher A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Henderson, Brian E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hung, Rayjean J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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URN: |
urn:nbn:de:hbz:38-265418 |
DOI: |
10.1158/0008-5472.CAN-15-2980 |
Journal or Publication Title: |
Cancer Res. |
Volume: |
76 |
Number: |
17 |
Page Range: |
S. 5103 - 5115 |
Date: |
2016 |
Publisher: |
AMER ASSOC CANCER RESEARCH |
Place of Publication: |
PHILADELPHIA |
ISSN: |
1538-7445 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
SUSCEPTIBILITY LOCI; IDENTIFIES 2; GENETIC POLYMORPHISMS; AGGRESSIVE PROSTATE; AFRICAN ANCESTRY; COMMON VARIANTS; GASTRIC-CANCER; CELL CARCINOMA; RISK LOCI; METAANALYSIS | Multiple languages | Oncology | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/26541 |
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