Fehringer, Gordon, Kraft, Peter ORCID: 0000-0002-4472-8103, Pharoah, Paul D., Eeles, Rosalind A., Chatterjee, Nilanjan, Schumacher, Fredrick R., Schildkraut, Joellen M., Lindstrom, Sara, Brennan, Paul, Bickeboller, Heike ORCID: 0000-0002-3361-5488, Houlston, Richard S., Landi, Maria Teresa, Caporaso, Neil, Risch, Angela ORCID: 0000-0002-8026-5505, Al Olama, Ali Amin, Berndt, Sonja I., Giovannucci, Edward L., Gronberg, Henrik, Kote-Jarai, Zsofia, Ma, Jing, Muir, Kenneth, Stampfer, Meir J., Stevens, Victoria L., Wiklund, Fredrik, Willett, Walter C., Goode, Ellen L., Permuth, Jennifer B., Risch, Harvey A., Reid, Brett M., Bezieau, Stephane, Brenner, Hermann ORCID: 0000-0002-6129-1572, Chan, Andrew T., Chang-Claude, Jenny, Hudson, Thomas J., Kocarnik, Jonathan K., Newcomb, Polly A., Schoen, Robert E., Slattery, Martha L., White, Emily, Adank, Muriel A., Ahsan, Habibul, Aittomaki, Kristiina, Baglietto, Laura ORCID: 0000-0002-8193-7529, Blomquist, Carl, Canzian, Federico ORCID: 0000-0002-4261-4583, Czene, Kamila, dos-Santos-Silva, Isabel, Eliassen, A. Heather, Figueroa, Jonine D., Flesch-Janys, Dieter, Fletcher, Olivia ORCID: 0000-0001-9387-7116, Garcia-Closas, Montserrat, Gaudet, Mia M., Johnson, Nichola, Hall, Per, Hazra, Aditi, Hein, Rebecca, Hofman, Albert, Hopper, John L., Irwanto, Astrid, Johansson, Mattias ORCID: 0000-0002-3116-5081, Kaaks, Rudolf, Kibriya, Muhammad G., Lichtner, Peter, Liu, Jianjun ORCID: 0000-0002-3255-3019, Lund, Eiliv, Makalic, Enes, Meindl, Alfons, Muller-Myhsok, Bertram, Muranen, Taru A., Nevanlinna, Heli, Peeters, Petra H., Peto, Julian, Prentice, Ross L., Rahman, Nazneen, Sanchez, Maria Jose, Schmidt, Daniel F., Schmutzler, Rita K., Southey, Melissa C., Tamimi, Rulla, Travis, Ruth C., Turnbull, Clare, Uitterlinden, Andre G., Wang, Zhaoming ORCID: 0000-0001-7556-3869, Whittemore, Alice S., Yang, Xiaohong R., Zheng, Wei ORCID: 0000-0003-1226-070X, Buchanan, Daniel D., Casey, Graham, Conti, David V., Edlund, Christopher K., Gallinger, Steven, Haile, Robert W., Jenkins, Mark ORCID: 0000-0002-8964-6160, Le Marchand, Loic, Li, Li, Lindor, Noralene M., Schmit, Stephanie L. ORCID: 0000-0001-5931-1194, Thibodeau, Stephen N., Woods, Michael O., Rafnar, Thorunn, Gudmundsson, Julius, Stacey, Simon N., Stefansson, Kari, Sulem, Patrick, Chen, Y. Ann, Tyrer, Jonathan P., Christiani, David C., Wei, Yongyue, Shen, Hongbing ORCID: 0000-0002-2581-5906, Hu, Zhibin, Shu, Xiao-Ou, Shiraishi, Kouya, Takahashi, Atsushi, Bosse, Yohan, Obeidat, Ma'en, Nickle, David, Timens, Wim ORCID: 0000-0002-4146-6363, Freedman, Matthew L., Li, Qiyuan, Seminara, Daniela, Chanock, Stephen J., Gong, Jian, Peters, Ulrike, Gruber, Stephen B., Amos, Christopher I., Sellers, Thomas A., Easton, Douglas F., Hunter, David J., Haiman, Christopher A., Henderson, Brian E. and Hung, Rayjean J. (2016). Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. Cancer Res., 76 (17). S. 5103 - 5115. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Full text not available from this repository.

Abstract

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus atCDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. (C) 2016 AACR.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fehringer, GordonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraft, PeterUNSPECIFIEDorcid.org/0000-0002-4472-8103UNSPECIFIED
Pharoah, Paul D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, Rosalind A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chatterjee, NilanjanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumacher, Fredrick R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schildkraut, Joellen M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindstrom, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brennan, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickeboller, HeikeUNSPECIFIEDorcid.org/0000-0002-3361-5488UNSPECIFIED
Houlston, Richard S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landi, Maria TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caporaso, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Risch, AngelaUNSPECIFIEDorcid.org/0000-0002-8026-5505UNSPECIFIED
Al Olama, Ali AminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berndt, Sonja I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giovannucci, Edward L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gronberg, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kote-Jarai, ZsofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ma, JingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muir, KennethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stampfer, Meir J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stevens, Victoria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiklund, FredrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willett, Walter C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goode, Ellen L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Permuth, Jennifer B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Risch, Harvey A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reid, Brett M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bezieau, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brenner, HermannUNSPECIFIEDorcid.org/0000-0002-6129-1572UNSPECIFIED
Chan, Andrew T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang-Claude, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hudson, Thomas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kocarnik, Jonathan K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Newcomb, Polly A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoen, Robert E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slattery, Martha L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
White, EmilyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adank, Muriel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahsan, HabibulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aittomaki, KristiinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baglietto, LauraUNSPECIFIEDorcid.org/0000-0002-8193-7529UNSPECIFIED
Blomquist, CarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canzian, FedericoUNSPECIFIEDorcid.org/0000-0002-4261-4583UNSPECIFIED
Czene, KamilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
dos-Santos-Silva, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eliassen, A. HeatherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Figueroa, Jonine D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flesch-Janys, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fletcher, OliviaUNSPECIFIEDorcid.org/0000-0001-9387-7116UNSPECIFIED
Garcia-Closas, MontserratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaudet, Mia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, NicholaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hall, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hazra, AditiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hein, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofman, AlbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Irwanto, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johansson, MattiasUNSPECIFIEDorcid.org/0000-0002-3116-5081UNSPECIFIED
Kaaks, RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kibriya, Muhammad G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lichtner, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, JianjunUNSPECIFIEDorcid.org/0000-0002-3255-3019UNSPECIFIED
Lund, EilivUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makalic, EnesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meindl, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller-Myhsok, BertramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muranen, Taru A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nevanlinna, HeliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peeters, Petra H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peto, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prentice, Ross L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahman, NazneenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez, Maria JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Daniel F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, Melissa C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tamimi, RullaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Travis, Ruth C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turnbull, ClareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uitterlinden, Andre G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, ZhaomingUNSPECIFIEDorcid.org/0000-0001-7556-3869UNSPECIFIED
Whittemore, Alice S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, Xiaohong R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zheng, WeiUNSPECIFIEDorcid.org/0000-0003-1226-070XUNSPECIFIED
Buchanan, Daniel D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casey, GrahamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conti, David V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edlund, Christopher K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallinger, StevenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haile, Robert W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenkins, MarkUNSPECIFIEDorcid.org/0000-0002-8964-6160UNSPECIFIED
Le Marchand, LoicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, LiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindor, Noralene M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmit, Stephanie L.UNSPECIFIEDorcid.org/0000-0001-5931-1194UNSPECIFIED
Thibodeau, Stephen N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woods, Michael O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rafnar, ThorunnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gudmundsson, JuliusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stacey, Simon N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stefansson, KariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sulem, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, Y. AnnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tyrer, Jonathan P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Christiani, David C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wei, YongyueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shen, HongbingUNSPECIFIEDorcid.org/0000-0002-2581-5906UNSPECIFIED
Hu, ZhibinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shu, Xiao-OuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shiraishi, KouyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Takahashi, AtsushiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bosse, YohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obeidat, Ma'enUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nickle, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timens, WimUNSPECIFIEDorcid.org/0000-0002-4146-6363UNSPECIFIED
Freedman, Matthew L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, QiyuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seminara, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chanock, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gong, JianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruber, Stephen B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amos, Christopher I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sellers, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunter, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haiman, Christopher A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henderson, Brian E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hung, Rayjean J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-265418
DOI: 10.1158/0008-5472.CAN-15-2980
Journal or Publication Title: Cancer Res.
Volume: 76
Number: 17
Page Range: S. 5103 - 5115
Date: 2016
Publisher: AMER ASSOC CANCER RESEARCH
Place of Publication: PHILADELPHIA
ISSN: 1538-7445
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUSCEPTIBILITY LOCI; IDENTIFIES 2; GENETIC POLYMORPHISMS; AGGRESSIVE PROSTATE; AFRICAN ANCESTRY; COMMON VARIANTS; GASTRIC-CANCER; CELL CARCINOMA; RISK LOCI; METAANALYSISMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26541

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