Formicola, Daniela ORCID: 0000-0001-9128-9775, Petrosino, Giuseppe ORCID: 0000-0002-2835-4308, Lasorsa, Vito Alessandro, Pignataro, Piero, Cimmino, Flora ORCID: 0000-0003-1538-9285, Vetrella, Simona, Longo, Luca ORCID: 0000-0002-5153-4243, Tonini, Gian Paolo, Oberthuer, Andre, Iolascon, Achille, Fischer, Matthias and Capasso, Mario ORCID: 0000-0003-3306-1259 (2016). An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma. J. Transl. Med., 14. LONDON: BIOMED CENTRAL LTD. ISSN 1479-5876
Full text not available from this repository.Abstract
Background: The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade. Patients and methods: Using microarray analyses of 342 primary tumors, we here developed and validated an easy to use gene expression-based risk score including 18 genes, which can robustly predict the outcome of stage 4 patients. Results: This classifier was a significant predictor of overall survival in two independent validation cohorts [ cohort 1 (n = 214): P = 6.3 x 10(-5); cohort 2 (n = 27): P = 3.1 x 10(-2)]. The prognostic value of the risk score was validated by multivariate analysis including the established markers age and MYCN status (P = 0.027). In the pooled validation cohorts (n = 241), integration of the risk score with the age and/or MYCN status identified subgroups with significantly differing overall survival (ranging from 35 to 100 %). Conclusion: Together, the 18-gene risk score classifier can identify patients with stage 4 NB with favorable outcome and may therefore improve risk assessment and treatment stratification of NB patients with disseminated disease.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-275657 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1186/s12967-016-0896-7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | J. Transl. Med. | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Volume: | 14 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Date: | 2016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | BIOMED CENTRAL LTD | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1479-5876 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/27565 |
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