Formicola, Daniela ORCID: 0000-0001-9128-9775, Petrosino, Giuseppe ORCID: 0000-0002-2835-4308, Lasorsa, Vito Alessandro, Pignataro, Piero, Cimmino, Flora ORCID: 0000-0003-1538-9285, Vetrella, Simona, Longo, Luca ORCID: 0000-0002-5153-4243, Tonini, Gian Paolo, Oberthuer, Andre, Iolascon, Achille, Fischer, Matthias and Capasso, Mario ORCID: 0000-0003-3306-1259 (2016). An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma. J. Transl. Med., 14. LONDON: BIOMED CENTRAL LTD. ISSN 1479-5876

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Abstract

Background: The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade. Patients and methods: Using microarray analyses of 342 primary tumors, we here developed and validated an easy to use gene expression-based risk score including 18 genes, which can robustly predict the outcome of stage 4 patients. Results: This classifier was a significant predictor of overall survival in two independent validation cohorts [ cohort 1 (n = 214): P = 6.3 x 10(-5); cohort 2 (n = 27): P = 3.1 x 10(-2)]. The prognostic value of the risk score was validated by multivariate analysis including the established markers age and MYCN status (P = 0.027). In the pooled validation cohorts (n = 241), integration of the risk score with the age and/or MYCN status identified subgroups with significantly differing overall survival (ranging from 35 to 100 %). Conclusion: Together, the 18-gene risk score classifier can identify patients with stage 4 NB with favorable outcome and may therefore improve risk assessment and treatment stratification of NB patients with disseminated disease.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Formicola, DanielaUNSPECIFIEDorcid.org/0000-0001-9128-9775UNSPECIFIED
Petrosino, GiuseppeUNSPECIFIEDorcid.org/0000-0002-2835-4308UNSPECIFIED
Lasorsa, Vito AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pignataro, PieroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cimmino, FloraUNSPECIFIEDorcid.org/0000-0003-1538-9285UNSPECIFIED
Vetrella, SimonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Longo, LucaUNSPECIFIEDorcid.org/0000-0002-5153-4243UNSPECIFIED
Tonini, Gian PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oberthuer, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iolascon, AchilleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capasso, MarioUNSPECIFIEDorcid.org/0000-0003-3306-1259UNSPECIFIED
URN: urn:nbn:de:hbz:38-275657
DOI: 10.1186/s12967-016-0896-7
Journal or Publication Title: J. Transl. Med.
Volume: 14
Date: 2016
Publisher: BIOMED CENTRAL LTD
Place of Publication: LONDON
ISSN: 1479-5876
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
METASTATIC NEUROBLASTOMA; NERVOUS-SYSTEM; MICROARRAY; SIGNATURE; CANCER; CELLS; RISK; DIFFERENTIATION; PROLIFERATION; AMPLIFICATIONMultiple languages
Medicine, Research & ExperimentalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27565

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