Universität zu Köln

Reale, Carla ORCID: 0000-0001-7682-4784, Iervolino, Anna, Scudiero, Ivan, Ferravante, Angela, D'Andrea, Luca Egildo, Mazzone, Pellegrino, Zotti, Tiziana, Leonardi, Antonio, Roberto, Luca, Zannini, Mariastella, de Cristofaro, Tiziana, Shanmugakonar, Muralitharan, Capasso, Giovambattista ORCID: 0000-0003-3469-8614, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Vito, Pasquale and Stilo, Romania (2016). NF-B Essential Modulator (NEMO) Is Critical for Thyroid Function. J. Biol. Chem., 291 (11). S. 5765 - 5774. BETHESDA: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC. ISSN 1083-351X

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Abstract

The I-B kinase (IKK) subunit NEMO/IKK (NEMO) is an adapter molecule that is critical for canonical activation of NF-B, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis, and apoptosis. To explore the functional role of canonical NF-B signaling in thyroid gland differentiation and function, we have generated a murine strain bearing a genetic deletion of the NEMO locus in thyroid. Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. Histological and molecular analysis indicate that absence of NEMO in thyrocytes results in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid differentiation markers and ongoing apoptosis. Thus, NEMO-dependent signaling is essential for normal thyroid physiology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reale, Carla UNSPECIFIED orcid.org/0000-0001-7682-4784 UNSPECIFIED Iervolino, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Scudiero, Ivan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferravante, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Andrea, Luca Egildo UNSPECIFIED UNSPECIFIED UNSPECIFIED Mazzone, Pellegrino UNSPECIFIED UNSPECIFIED UNSPECIFIED Zotti, Tiziana UNSPECIFIED UNSPECIFIED UNSPECIFIED Leonardi, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Roberto, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Zannini, Mariastella UNSPECIFIED UNSPECIFIED UNSPECIFIED de Cristofaro, Tiziana UNSPECIFIED UNSPECIFIED UNSPECIFIED Shanmugakonar, Muralitharan UNSPECIFIED UNSPECIFIED UNSPECIFIED Capasso, Giovambattista UNSPECIFIED orcid.org/0000-0003-3469-8614 UNSPECIFIED Pasparakis, Manolis UNSPECIFIED orcid.org/0000-0002-9870-0966 UNSPECIFIED Vito, Pasquale UNSPECIFIED UNSPECIFIED UNSPECIFIED Stilo, Romania UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-281567
DOI:	10.1074/jbc.M115.711697
Journal or Publication Title:	J. Biol. Chem.
Volume:	291
Number:	11
Page Range:	S. 5765 - 5774
Date:	2016
Publisher:	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Place of Publication:	BETHESDA
ISSN:	1083-351X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HYPOHIDROTIC ECTODERMAL DYSPLASIA; SEVERE LIVER DEGENERATION; ALPHA-INDUCED APOPTOSIS; GAMMA-DEFICIENT MICE; KAPPA-B; EMBRYONIC LETHALITY; GENE-EXPRESSION; CELL-DEATH; C-FLIP; ACTIVATION Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28156