Rasche, Andrea ORCID: 0000-0001-6693-1180, de Carvalho Dominguez Souza, Breno Frederico and Drexler, Jan Felix ORCID: 0000-0002-3509-0232 (2016). Bat hepadnaviruses and the origins of primate hepatitis B viruses. Curr. Opin. Virol., 16. S. 86 - 95. OXFORD: ELSEVIER SCI LTD. ISSN 1879-6257
Full text not available from this repository.Abstract
The origin of primate HBV (family Hepadnaviridae) is unknown. Hepadnaviruses are ancient pathogens and may have been associated with old mammalian lineages like bats for prolonged time. Indeed, the genetic diversity of bat hepadnaviruses exceeds that of extant hepadnaviruses in other host orders, suggesting a long evolution of hepadnaviruses in bats. Strikingly, a recently detected New World bat hepadnavirus is antigenically related to HBV and can infect human hepatocytes. Together with genetically diverse hepadnaviruses from New World rodents and a non-human primate, these viruses argue for a New World origin of ancestral orthohepadnaviruses. Multiple host switches of bat and primate viruses are evident and bats are likely sources of ancestral hepadnaviruses acquired by primates.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-284921 | ||||||||||||||||
DOI: | 10.1016/j.coviro.2016.01.015 | ||||||||||||||||
Journal or Publication Title: | Curr. Opin. Virol. | ||||||||||||||||
Volume: | 16 | ||||||||||||||||
Page Range: | S. 86 - 95 | ||||||||||||||||
Date: | 2016 | ||||||||||||||||
Publisher: | ELSEVIER SCI LTD | ||||||||||||||||
Place of Publication: | OXFORD | ||||||||||||||||
ISSN: | 1879-6257 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
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Refereed: | Yes | ||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/28492 |
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