Schermer, Bernhard ORCID: 0000-0002-5194-9000 and Benzing, Thomas (2016). Endothelial cilia protect against atherosclerosis. EMBO Rep., 17 (2). S. 125 - 127. HOBOKEN: WILEY-BLACKWELL. ISSN 1469-3178
Full text not available from this repository.Abstract
Research over the past 15 years has established that defective primary cilia play a fundamental role in the pathogenesis of various genetic and acquired human diseases now termed ciliopathies. A new study, published in this issue of EMBO reports, expands the spectrum of cilia-related diseases by uncovering a role for primary cilia in preventing cardiovascular disease. Dinsmore and Reiter show that lack of endothelial cilia in the aorta results in accelerated development of atherosclerotic lesions in a mouse model of atherosclerosis on a high-fat, high-cholesterol diet. Loss of endothelial cilia further increases inflammatory gene expression and reduces vasoprotective eNOS activity . In summary, this interesting study identifies a role for aortic endothelial cilia to protect against atherosclerosis.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-285594 | ||||||||||||
DOI: | 10.15252/embr.201541890 | ||||||||||||
Journal or Publication Title: | EMBO Rep. | ||||||||||||
Volume: | 17 | ||||||||||||
Number: | 2 | ||||||||||||
Page Range: | S. 125 - 127 | ||||||||||||
Date: | 2016 | ||||||||||||
Publisher: | WILEY-BLACKWELL | ||||||||||||
Place of Publication: | HOBOKEN | ||||||||||||
ISSN: | 1469-3178 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/28559 |
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