Universität zu Köln

Schermer, Bernhard ORCID: 0000-0002-5194-9000 and Benzing, Thomas (2016). Endothelial cilia protect against atherosclerosis. EMBO Rep., 17 (2). S. 125 - 127. HOBOKEN: WILEY-BLACKWELL. ISSN 1469-3178

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Abstract

Research over the past 15 years has established that defective primary cilia play a fundamental role in the pathogenesis of various genetic and acquired human diseases now termed ciliopathies. A new study, published in this issue of EMBO reports, expands the spectrum of cilia-related diseases by uncovering a role for primary cilia in preventing cardiovascular disease. Dinsmore and Reiter show that lack of endothelial cilia in the aorta results in accelerated development of atherosclerotic lesions in a mouse model of atherosclerosis on a high-fat, high-cholesterol diet. Loss of endothelial cilia further increases inflammatory gene expression and reduces vasoprotective eNOS activity . In summary, this interesting study identifies a role for aortic endothelial cilia to protect against atherosclerosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schermer, Bernhard UNSPECIFIED orcid.org/0000-0002-5194-9000 UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-285594
DOI:	10.15252/embr.201541890
Journal or Publication Title:	EMBO Rep.
Volume:	17
Number:	2
Page Range:	S. 125 - 127
Date:	2016
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1469-3178
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DISEASE Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28559