Universität zu Köln

Schultze-Lutter, Frauke, Debbane, Martin ORCID: 0000-0002-4677-8753, Theodoridou, Anastasia, Wood, Stephen J., Raballo, Andrea ORCID: 0000-0003-3709-4111, Michel, Chantal ORCID: 0000-0003-1165-6681, Schmidt, Stefanie J., Kindler, Jochen ORCID: 0000-0002-9034-2770, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364 and Uhlhaas, Peter J. (2016). Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets. Front. Psychiatry, 7. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-0640

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Abstract

In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self -experienced expression of the underlying neurobiological aberrations of the disease. Other characteristic symptoms of psychosis (e.g., delusions and hallucinations) were conceptualized as secondary phenomena, resulting from dysfunctional beliefs and suboptimal coping styles with emerging BSs and/or concomitant stressors. While BSs can occur in many mental disorders, in particular affective disorders, a subset of perceptive and cognitive BSs appear to be specific to psychosis and are currently employed in two alternative risk criteria. However, despite their clinical recognition in the early detection of psychosis, neurobiological research on the aetiopathology of psychosis with neuroimaging methods has only just begun to consider the neural correlate of BSs. This perspective paper reviews the emerging evidence of an association between BSs and aberrant brain activation, connectivity patterns, and metabolism, and outlines promising routes for the use of BSs in aetiopathological research on psychosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Debbane, Martin UNSPECIFIED orcid.org/0000-0002-4677-8753 UNSPECIFIED Theodoridou, Anastasia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wood, Stephen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Raballo, Andrea UNSPECIFIED orcid.org/0000-0003-3709-4111 UNSPECIFIED Michel, Chantal UNSPECIFIED orcid.org/0000-0003-1165-6681 UNSPECIFIED Schmidt, Stefanie J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kindler, Jochen UNSPECIFIED orcid.org/0000-0002-9034-2770 UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Uhlhaas, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-286947
DOI:	10.3389/fpsyt.2016.00009
Journal or Publication Title:	Front. Psychiatry
Volume:	7
Date:	2016
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-0640
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH RISK; SCHIZOPHRENIA SPECTRUM PATIENTS; CLINICAL HIGH-RISK; 1ST-EPISODE SCHIZOPHRENIA; SUBJECTIVE EXPERIENCE; SELF-EXPERIENCE; MENTAL STATES; PSYCHIATRIC-DISORDERS; DOPAMINE SYNTHESIS; DYSFUNCTION Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28694