Universität zu Köln

Steffen, Julia K., Jergas, Hannah, Petry-Schmelzer, Jan N., Dembek, Till A., Thies, Tabea ORCID: 0000-0001-9149-3143, Jost, Stefanie T., Dafsari, Haidar S., Kessler, Josef, Wirths, Jochen, Fink, Gereon R., Visser-Vandewalle, Veerle and Barbe, Michael T. (2020). Thalamic Deep Brain Stimulation in Essential Tremor Plus Is as Effective as in Essential Tremor. Brain Sci., 10 (12). BASEL: MDPI. ISSN 2076-3425

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Abstract

The new essential tremor (ET) classification defined ET-plus (ET-p) as an ET subgroup with additional neurological signs besides action tremor. While deep brain stimulation (DBS) is effective in ET, there are no studies specifically addressing DBS effects in ET-p. 44 patients with medication-refractory ET and thalamic/subthalamic DBS implanted at our center were postoperatively classified into ET and ET-p according to preoperative documentation. Tremor suppression with DBS (stimulation ON vs. preoperative baseline and vs. stimulation OFF), measured via the Fahn-Tolosa-Marin tremor rating scale (TRS), stimulation parameters, and the location of active contacts were compared between patients classified as ET and ET-p. TRS scores at baseline were higher in ET-p. ET-p patients showed comparable tremor reduction as patients with ET, albeit higher stimulation parameters were needed in ET-p. Active electrode contacts were located more dorsally in ET-p of uncertain reason. Our data show that DBS is similarly effective in ET-p compared to ET. TRS scores were higher in ET-p preoperatively, and higher stimulation parameters were needed for tremor reduction compared to ET. The latter may be related to a more dorsal location of active electrode contacts in the ET-p group of this cohort. Prospective studies are warranted to investigate DBS in ET-p further.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Steffen, Julia K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jergas, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Petry-Schmelzer, Jan N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, Till A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thies, Tabea UNSPECIFIED orcid.org/0000-0001-9149-3143 UNSPECIFIED Jost, Stefanie T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessler, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirths, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-309670
DOI:	10.3390/brainsci10120970
Journal or Publication Title:	Brain Sci.
Volume:	10
Number:	12
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3425
Language:	English
Faculty:	Faculty of Arts and Humanities
Divisions:	Faculty of Arts and Humanities > Fächergruppe 1: Kunstgeschichte, Musikwissenschaft, Medienkultur und Theater, Linguistik, IDH > Institut für Linguistik > Phonetik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/30967