Universität zu Köln

Rheinwalt, Karl Peter, Drebber, Uta, Schierwagen, Robert, Klein, Sabine, Neumann, Ulf Peter, Ulmer, Tom Florian, Plamper, Andreas, Kroh, Andreas, Schipper, Sandra, Odenthal, Margarete, Uschner, Frank Erhard, Lingohr, Philipp, Trebicka, Jonel ORCID: 0000-0002-7028-3881 and Brol, Maximilian Joseph (2020). Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity. J. Clin. Med., 9 (11). BASEL: MDPI. ISSN 2077-0383

Full text not available from this repository.

Abstract

Background. Bariatric surgery is a widely used treatment for morbid obesity. Prediction of postoperative weight loss currently relies on prediction models, which mostly overestimate patients' weight loss. Data about the influence of Non-alcoholic fatty liver disease (NAFLD) on early postoperative weight loss are scarce. Methods. This prospective, single-center cohort study included 143 patients receiving laparoscopic gastric bypass surgery (One Anastomosis-Mini Gastric Bypass (OAGB-MGB) or Roux-en-Y Gastric Bypass (RYGB)). Liver biopsies were acquired at surgery. NAFLD activity score (NAS) assigned patients to No NAFLD, NAFL or NASH. Follow up data were collected at 3, 6 and 12 months. Results. In total, 49.7% of patients had NASH, while 41.3% had NAFL. Compared with the No NAFLD group, NAFL and NASH showed higher body-mass-index (BMI) at follow-up (6 months: 31.0 kg/m(2) vs. 36.8 kg/m(2) and 36.1 kg/m(2), 12 months: 27.0 kg/m(2) vs. 34.4 and 32.8 kg/m(2)) and lower percentage of total body weight loss (%TBWL): (6 months: 27.1% vs. 23.3% and 24.4%; 12 months: 38.5% vs. 30.1 and 32.6%). Linear regression of NAS points significantly predicts percentage of excessive weight loss (%EWL) after 6 months (Cologne-weight-loss-prediction-score). Conclusions. Histopathological presence of NAFLD might lead to inferior postoperative weight reduction after gastric bypass surgery. The mechanisms underlying this observation should be further studied.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rheinwalt, Karl Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Schierwagen, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Ulf Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Ulmer, Tom Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Plamper, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroh, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schipper, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED Uschner, Frank Erhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Lingohr, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Trebicka, Jonel UNSPECIFIED orcid.org/0000-0002-7028-3881 UNSPECIFIED Brol, Maximilian Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-313024
DOI:	10.3390/jcm9113430
Journal or Publication Title:	J. Clin. Med.
Volume:	9
Number:	11
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SIMPLE NONINVASIVE INDEX; BARIATRIC SURGERY; SIGNIFICANT FIBROSIS; SLEEVE GASTRECTOMY; SCORING SYSTEM; VALIDATION Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31302