Koenigschulte, W., Civai, C., Hildebrand, P., Gaber, T. J., Fink, G. R. and Zepf, F. D. (2020). Effects of serotonin depletion and dopamine depletion on bimodal divided attention. World J. Biol. Psychiatry, 21 (3). S. 183 - 195. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1814-1412
Full text not available from this repository.Abstract
Objectives: This study aimed to explore the effects of acute phenylalanine tyrosine depletion (APTD) and acute tryptophan depletion (ATD) on bimodal divided attention. A balanced amino acid mixture (BAL) served as control condition. Methods: Fifty-three healthy adults (final analyzed sample was N = 49, age: M = 23.8 years) were randomly assigned to APTD, ATD or BAL in a double-blind, between-subject approach. Divided attention was assessed after 4 h. Blood samples were taken before and 6 h after challenge intake. Results: Amino acid concentrations following challenge intake significantly decreased (all P <= 0.01). There was a significant difference in the mean reaction time (RT) towards auditory stimuli, but not towards visual stimuli between the groups. Post-hoc comparison of mean RTs (auditory stimuli) showed a significant difference between ATD (RT = 604.0 ms, SD = 56.9 ms) and APTD (RT = 556.4 ms, SD = 54.2 ms; P = 0.037), but no RT difference between ATD and BAL or APTD and BAL (RT = 573.6 ms, SD = 45.7 ms). Conclusions: The results indicate a possible dissociation between the effects of a diminished brain 5-HT and DA synthesis on the performance in a bimodal divided attention task. The difference was exclusively observed within the RT towards auditory signals.
Item Type: | Journal Article | ||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-340918 | ||||||||||||||||||||||||||||
DOI: | 10.1080/15622975.2018.1532110 | ||||||||||||||||||||||||||||
Journal or Publication Title: | World J. Biol. Psychiatry | ||||||||||||||||||||||||||||
Volume: | 21 | ||||||||||||||||||||||||||||
Number: | 3 | ||||||||||||||||||||||||||||
Page Range: | S. 183 - 195 | ||||||||||||||||||||||||||||
Date: | 2020 | ||||||||||||||||||||||||||||
Publisher: | TAYLOR & FRANCIS LTD | ||||||||||||||||||||||||||||
Place of Publication: | ABINGDON | ||||||||||||||||||||||||||||
ISSN: | 1814-1412 | ||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/34091 |
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