Buchholz, Christian J., Friedel, Thorsten and Buening, Hildegard (2015). Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery. Trends Biotechnol., 33 (12). S. 777 - 791. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1879-3096
Full text not available from this repository.Abstract
Recent progress in gene transfer technology enables the delivery of genes precisely to the application-relevant cell type ex vivo on cultivated primary cells or in vivo on local or systemic administration. Gene vectors based on lentiviruses or adeno-associated viruses can be engineered such that they use a cell surface marker of choice for cell entry instead of their natural receptors. Binding to the surface marker is mediated by a targeting ligand displayed on the vector particle surface, which can be a peptide, single-chain antibody, or designed ankyrin repeat protein. Examples include vectors that deliver genes to specialized endothelial cells or lymphocytes, tumor cells, or particular cells of the nervous system with potential applications in gene function studies and molecular medicine.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-386498 | ||||||||||||||||
DOI: | 10.1016/j.tibtech.2015.09.008 | ||||||||||||||||
Journal or Publication Title: | Trends Biotechnol. | ||||||||||||||||
Volume: | 33 | ||||||||||||||||
Number: | 12 | ||||||||||||||||
Page Range: | S. 777 - 791 | ||||||||||||||||
Date: | 2015 | ||||||||||||||||
Publisher: | ELSEVIER SCIENCE LONDON | ||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||
ISSN: | 1879-3096 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/38649 |
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