Universität zu Köln

Buchholz, Christian J., Friedel, Thorsten and Buening, Hildegard (2015). Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery. Trends Biotechnol., 33 (12). S. 777 - 791. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1879-3096

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Abstract

Recent progress in gene transfer technology enables the delivery of genes precisely to the application-relevant cell type ex vivo on cultivated primary cells or in vivo on local or systemic administration. Gene vectors based on lentiviruses or adeno-associated viruses can be engineered such that they use a cell surface marker of choice for cell entry instead of their natural receptors. Binding to the surface marker is mediated by a targeting ligand displayed on the vector particle surface, which can be a peptide, single-chain antibody, or designed ankyrin repeat protein. Examples include vectors that deliver genes to specialized endothelial cells or lymphocytes, tumor cells, or particular cells of the nervous system with potential applications in gene function studies and molecular medicine.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Buchholz, Christian J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedel, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Buening, Hildegard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386498
DOI:	10.1016/j.tibtech.2015.09.008
Journal or Publication Title:	Trends Biotechnol.
Volume:	33
Number:	12
Page Range:	S. 777 - 791
Date:	2015
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1879-3096
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADENOASSOCIATED VIRUS; IN-VIVO; LENTIVIRAL VECTORS; T-CELLS; VSV-G; TARGETED TRANSDUCTION; ENDOTHELIAL-CELLS; SYSTEMIC DELIVERY; BIPOLAR CELLS; RECEPTOR Multiple languages Biotechnology & Applied Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38649