Universität zu Köln

Otipoby, Kevin L., Waisman, Ari ORCID: 0000-0003-4304-8234, Derudder, Emmanuel ORCID: 0000-0003-1421-4045, Srinivasan, Lakshmi, Franklin, Andrew and Rajewsky, Klaus ORCID: 0000-0002-6633-6370 (2015). The B-cell antigen receptor integrates adaptive and innate immune signals. Proc. Natl. Acad. Sci. U. S. A., 112 (39). S. 12145 - 12151. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3 beta and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Otipoby, Kevin L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Waisman, Ari UNSPECIFIED orcid.org/0000-0003-4304-8234 UNSPECIFIED Derudder, Emmanuel UNSPECIFIED orcid.org/0000-0003-1421-4045 UNSPECIFIED Srinivasan, Lakshmi UNSPECIFIED UNSPECIFIED UNSPECIFIED Franklin, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED Rajewsky, Klaus UNSPECIFIED orcid.org/0000-0002-6633-6370 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-392618
DOI:	10.1073/pnas.1516428112
Journal or Publication Title:	Proc. Natl. Acad. Sci. U. S. A.
Volume:	112
Number:	39
Page Range:	S. 12145 - 12151
Date:	2015
Publisher:	NATL ACAD SCIENCES
Place of Publication:	WASHINGTON
ISSN:	0027-8424
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOUSE IMMUNOGLOBULIN ANTIBODIES; LYMPHOCYTE DEVELOPMENT; KAPPA-B; GENE; ACTIVATION; KINASE; EXPRESSION; RESPONSES; SURVIVAL; PATHWAY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39261