Rhiem, Kerstin (2015). Preventive surgery options for women with hereditary breast and ovarian cancer. Med. Genet., 27 (2). S. 231 - 237. NEW YORK: SPRINGER. ISSN 1863-5490
Full text not available from this repository.Abstract
The publication in 1994 and 1995 of articles on the two high-risk genes for hereditary breast and ovarian cancer, BRCA1 and BRCA2, allowed genetic testing in families with the determination of their specific risk. Over the last 20 years, protocols for genetic counselling have been developed, breast and ovarian cancer frequencies and clinical phenotypes have been determined, and the efficiency and rationale for risk adjusted preventive measures and specific clinical interventions have been examined. This enables us to inform patients within non directive counselling about their individual risk and to accompany them to a preference sensitive decision on risk adapted preventive and therapeutic measures. The most recent challenges include the approval of PARP inhibitors and the discovery of new risk genes. This manuscript focusses on the efficacy of risk-reducing mastectomy and salpingo-oophorectomy mainly in women carrying mutations in the BRCA1 and BRCA2 genes.
Item Type: | Journal Article | ||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-397378 | ||||||||
DOI: | 10.1007/s11825-015-0046-2 | ||||||||
Journal or Publication Title: | Med. Genet. | ||||||||
Volume: | 27 | ||||||||
Number: | 2 | ||||||||
Page Range: | S. 231 - 237 | ||||||||
Date: | 2015 | ||||||||
Publisher: | SPRINGER | ||||||||
Place of Publication: | NEW YORK | ||||||||
ISSN: | 1863-5490 | ||||||||
Language: | German | ||||||||
Faculty: | Unspecified | ||||||||
Divisions: | Unspecified | ||||||||
Subjects: | no entry | ||||||||
Uncontrolled Keywords: |
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URI: | http://kups.ub.uni-koeln.de/id/eprint/39737 |
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