Universität zu Köln

Rhiem, Kerstin (2015). Preventive surgery options for women with hereditary breast and ovarian cancer. Med. Genet., 27 (2). S. 231 - 237. NEW YORK: SPRINGER. ISSN 1863-5490

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Abstract

The publication in 1994 and 1995 of articles on the two high-risk genes for hereditary breast and ovarian cancer, BRCA1 and BRCA2, allowed genetic testing in families with the determination of their specific risk. Over the last 20 years, protocols for genetic counselling have been developed, breast and ovarian cancer frequencies and clinical phenotypes have been determined, and the efficiency and rationale for risk adjusted preventive measures and specific clinical interventions have been examined. This enables us to inform patients within non directive counselling about their individual risk and to accompany them to a preference sensitive decision on risk adapted preventive and therapeutic measures. The most recent challenges include the approval of PARP inhibitors and the discovery of new risk genes. This manuscript focusses on the efficacy of risk-reducing mastectomy and salpingo-oophorectomy mainly in women carrying mutations in the BRCA1 and BRCA2 genes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397378
DOI:	10.1007/s11825-015-0046-2
Journal or Publication Title:	Med. Genet.
Volume:	27
Number:	2
Page Range:	S. 231 - 237
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1863-5490
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRCA2 MUTATION CARRIERS; CONTRALATERAL PROPHYLACTIC MASTECTOMY; RISK-REDUCING SURGERY; 20-YEAR FOLLOW-UP; SALPINGO-OOPHORECTOMY; BILATERAL MASTECTOMY; COHORT; ASSOCIATION; PHENOTYPE; MORTALITY Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39737