Universität zu Köln

Mueller, Philipp, Martin, Kea, Theurich, Sebastian ORCID: 0000-0001-5706-8258, von Bergwelt-Baildon, Michael and Zippelius, Alfred (2014). Cancer chemotherapy agents target intratumoral dendritic cells to potentiate antitumor immunity. OncoImmunology, 3 (8). AUSTIN: LANDES BIOSCIENCE. ISSN 2162-402X

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Abstract

Cytotoxic drugs capable of killing cancer cells in conjunction with targeted conversion of tumor resident, tolerogenic dendritic cells (DCs) into efficient antigen presenting cells (APCs) are highly complementary therapeutic routes to boost antitumor immunity. Our data suggest that the microtubule-depolymerizing compounds Dolastatin 10 and Ansamitocin P3 may serve as prototypes for a class of agents that display this binary mode of action.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Kea UNSPECIFIED UNSPECIFIED UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Zippelius, Alfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433421
DOI:	10.4161/21624011.2014.954460
Journal or Publication Title:	OncoImmunology
Volume:	3
Number:	8
Date:	2014
Publisher:	LANDES BIOSCIENCE
Place of Publication:	AUSTIN
ISSN:	2162-402X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMMUNOTHERAPY; THERAPY; DEATH Multiple languages Oncology; Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43342