Mueller, Philipp, Martin, Kea, Theurich, Sebastian ORCID: 0000-0001-5706-8258, von Bergwelt-Baildon, Michael and Zippelius, Alfred (2014). Cancer chemotherapy agents target intratumoral dendritic cells to potentiate antitumor immunity. OncoImmunology, 3 (8). AUSTIN: LANDES BIOSCIENCE. ISSN 2162-402X

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Abstract

Cytotoxic drugs capable of killing cancer cells in conjunction with targeted conversion of tumor resident, tolerogenic dendritic cells (DCs) into efficient antigen presenting cells (APCs) are highly complementary therapeutic routes to boost antitumor immunity. Our data suggest that the microtubule-depolymerizing compounds Dolastatin 10 and Ansamitocin P3 may serve as prototypes for a class of agents that display this binary mode of action.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mueller, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, KeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Theurich, SebastianUNSPECIFIEDorcid.org/0000-0001-5706-8258UNSPECIFIED
von Bergwelt-Baildon, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zippelius, AlfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-433421
DOI: 10.4161/21624011.2014.954460
Journal or Publication Title: OncoImmunology
Volume: 3
Number: 8
Date: 2014
Publisher: LANDES BIOSCIENCE
Place of Publication: AUSTIN
ISSN: 2162-402X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IMMUNOTHERAPY; THERAPY; DEATHMultiple languages
Oncology; ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43342

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