Universität zu Köln

Antsiferova, Maria, Martin, Caroline, Huber, Marcel ORCID: 0000-0003-3821-2378, Feyerabend, Thorsten B., Foerster, Anja, Hartmann, Karin ORCID: 0000-0002-4595-8226, Rodewald, Hans-Reimer, Hohl, Daniel and Werner, Sabine ORCID: 0000-0001-7397-8710 (2013). Mast Cells Are Dispensable for Normal and Activin-Promoted Wound Healing and Skin Carcinogenesis. J. Immunol., 191 (12). S. 6147 - 6156. BETHESDA: AMER ASSOC IMMUNOLOGISTS. ISSN 1550-6606

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Abstract

The growth and differentiation factor activin A is a key regulator of tissue repair, inflammation, fibrosis, and tumorigenesis. However, the cellular targets, which mediate the different activin functions, are still largely unknown. In this study, we show that activin increases the number of mature mast cells in mouse skin in vivo. To determine the relevance of this finding for wound healing and skin carcinogenesis, we mated activin transgenic mice with CreMaster mice, which are characterized by Cre recombinase-mediated mast cell eradication. Using single-and double-mutant mice, we show that loss of mast cells neither affected the stimulatory effect of overexpressed activin on granulation tissue formation and reepithelialization of skin wounds nor its protumorigenic activity in a model of chemically induced skin carcinogenesis. Furthermore, mast cell deficiency did not alter wounding-induced inflammation and new tissue formation or chemically induced angiogenesis and tumorigenesis in mice with normal activin levels. These findings reveal that mast cells are not major targets of activin during wound healing and skin cancer development and also argue against nonredundant functions of mast cells in wound healing and skin carcinogenesis in general.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Antsiferova, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Huber, Marcel UNSPECIFIED orcid.org/0000-0003-3821-2378 UNSPECIFIED Feyerabend, Thorsten B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Karin UNSPECIFIED orcid.org/0000-0002-4595-8226 UNSPECIFIED Rodewald, Hans-Reimer UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohl, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Sabine UNSPECIFIED orcid.org/0000-0001-7397-8710 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470050
DOI:	10.4049/jimmunol.1301350
Journal or Publication Title:	J. Immunol.
Volume:	191
Number:	12
Page Range:	S. 6147 - 6156
Date:	2013
Publisher:	AMER ASSOC IMMUNOLOGISTS
Place of Publication:	BETHESDA
ISSN:	1550-6606
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSGENIC MICE; DEFICIENT MICE; TISSUE-REPAIR; INFLAMMATION; MORPHOGENESIS; KIT; EXPRESSION; GROWTH; CANCER; ROLES Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47005