Universität zu Köln

Ullmann, A. J., Akova, M., Herbrecht, R., Viscoli, C., Arendrup, M. C., Arikan-Akdagli, S., Bassetti, M., Bille, J., Calandra, T., Castagnola, E., Cornely, O. A., Donnelly, J. P., Garbino, J., Groll, A. H., Hope, W. W., Jensen, H. E., Kullberg, B. J., Lass-Floerl, C., Lortholary, O., Meersseman, W., Petrikkos, G., Richardson, M. D., Roilides, E., Verweij, P. E. and Cuenca-Estrella, M. (2012). ESCMID* guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT). Clin. Microbiol. Infect., 18. S. 53 - 68. OXFORD: ELSEVIER SCI LTD. ISSN 1469-0691

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Abstract

Clin Microbiol Infect 2012; 18 (Suppl. 7): 5367 Abstract Fungal diseases still play a major role in morbidity and mortality in patients with haematological malignancies, including those undergoing haematopoietic stem cell transplantation. Although Aspergillus and other filamentous fungal diseases remain a major concern, Candida infections are still a major cause of mortality. This part of the ESCMID guidelines focuses on this patient population and reviews pertaining to prophylaxis, empirical/pre-emptive and targeted therapy of Candida diseases. Anti-Candida prophylaxis is only recommended for patients receiving allogeneic stem cell transplantation. The authors recognize that the recommendations would have most likely been different if the purpose would have been prevention of all fungal infections (e.g. aspergillosis). In targeted treatment of candidaemia, recommendations for treatment are available for all echinocandins, that is anidulafungin (AI), caspofungin (AI) and micafungin (AI), although a warning for resistance is expressed. Liposomal amphotericin B received a BI recommendation due to higher number of reported adverse events in the trials. Amphotericin B deoxycholate should not be used (DII); and fluconazole was rated CI because of a change in epidemiology in some areas in Europe. Removal of central venous catheters is recommended during candidaemia but if catheter retention is a clinical necessity, treatment with an echinocandin is an option (CIIt). In chronic disseminated candidiasis therapy, recommendations are liposomal amphotericin B for 8 weeks (AIII), fluconazole for >3 months or other azoles (BIII). Granulocyte transfusions are only an option in desperate cases of patients with Candida disease and neutropenia (CIII).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ullmann, A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Akova, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbrecht, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Viscoli, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arendrup, M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arikan-Akdagli, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bassetti, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bille, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Calandra, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Castagnola, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Donnelly, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Garbino, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Groll, A. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hope, W. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jensen, H. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kullberg, B. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lass-Floerl, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lortholary, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meersseman, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrikkos, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Richardson, M. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roilides, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verweij, P. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cuenca-Estrella, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-477877
DOI:	10.1111/1469-0691.12041
Journal or Publication Title:	Clin. Microbiol. Infect.
Volume:	18
Page Range:	S. 53 - 68
Date:	2012
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1469-0691
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIPOSOMAL AMPHOTERICIN-B; INVASIVE FUNGAL-INFECTIONS; EMPIRICAL ANTIFUNGAL THERAPY; ITRACONAZOLE ORAL SOLUTION; ADJUVANT CORTICOSTEROID-THERAPY; TRIAL COMPARING ITRACONAZOLE; CLINICAL-PRACTICE GUIDELINES; BLOOD-STREAM INFECTIONS; DOUBLE-BLIND; NEUTROPENIC PATIENTS Multiple languages Infectious Diseases; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47787