Ullmann, A. J., Akova, M., Herbrecht, R., Viscoli, C., Arendrup, M. C., Arikan-Akdagli, S., Bassetti, M., Bille, J., Calandra, T., Castagnola, E., Cornely, O. A., Donnelly, J. P., Garbino, J., Groll, A. H., Hope, W. W., Jensen, H. E., Kullberg, B. J., Lass-Floerl, C., Lortholary, O., Meersseman, W., Petrikkos, G., Richardson, M. D., Roilides, E., Verweij, P. E. and Cuenca-Estrella, M. (2012). ESCMID* guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT). Clin. Microbiol. Infect., 18. S. 53 - 68. OXFORD: ELSEVIER SCI LTD. ISSN 1469-0691

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Abstract

Clin Microbiol Infect 2012; 18 (Suppl. 7): 5367 Abstract Fungal diseases still play a major role in morbidity and mortality in patients with haematological malignancies, including those undergoing haematopoietic stem cell transplantation. Although Aspergillus and other filamentous fungal diseases remain a major concern, Candida infections are still a major cause of mortality. This part of the ESCMID guidelines focuses on this patient population and reviews pertaining to prophylaxis, empirical/pre-emptive and targeted therapy of Candida diseases. Anti-Candida prophylaxis is only recommended for patients receiving allogeneic stem cell transplantation. The authors recognize that the recommendations would have most likely been different if the purpose would have been prevention of all fungal infections (e.g. aspergillosis). In targeted treatment of candidaemia, recommendations for treatment are available for all echinocandins, that is anidulafungin (AI), caspofungin (AI) and micafungin (AI), although a warning for resistance is expressed. Liposomal amphotericin B received a BI recommendation due to higher number of reported adverse events in the trials. Amphotericin B deoxycholate should not be used (DII); and fluconazole was rated CI because of a change in epidemiology in some areas in Europe. Removal of central venous catheters is recommended during candidaemia but if catheter retention is a clinical necessity, treatment with an echinocandin is an option (CIIt). In chronic disseminated candidiasis therapy, recommendations are liposomal amphotericin B for 8 weeks (AIII), fluconazole for >3 months or other azoles (BIII). Granulocyte transfusions are only an option in desperate cases of patients with Candida disease and neutropenia (CIII).

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ullmann, A. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akova, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herbrecht, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viscoli, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arendrup, M. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arikan-Akdagli, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bassetti, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bille, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calandra, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castagnola, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, O. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donnelly, J. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garbino, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groll, A. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hope, W. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen, H. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kullberg, B. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lass-Floerl, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lortholary, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meersseman, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petrikkos, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richardson, M. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roilides, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verweij, P. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuenca-Estrella, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-477877
DOI: 10.1111/1469-0691.12041
Journal or Publication Title: Clin. Microbiol. Infect.
Volume: 18
Page Range: S. 53 - 68
Date: 2012
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1469-0691
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LIPOSOMAL AMPHOTERICIN-B; INVASIVE FUNGAL-INFECTIONS; EMPIRICAL ANTIFUNGAL THERAPY; ITRACONAZOLE ORAL SOLUTION; ADJUVANT CORTICOSTEROID-THERAPY; TRIAL COMPARING ITRACONAZOLE; CLINICAL-PRACTICE GUIDELINES; BLOOD-STREAM INFECTIONS; DOUBLE-BLIND; NEUTROPENIC PATIENTSMultiple languages
Infectious Diseases; MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47787

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