Universität zu Köln

Xia, Xin R., Monteiro-Riviere, Nancy A., Mathur, Sanjay, Song, Xuefeng, Xiao, Lisong, Oldenberg, Steven J., Fadeel, Bengt and Riviere, Jim E. (2011). Mapping the Surface Adsorption Forces of Nanomaterials in Biological Systems. ACS Nano, 5 (11). S. 9074 - 9082. WASHINGTON: AMER CHEMICAL SOC. ISSN 1936-086X

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Abstract

The biological surface adsorption Index (BSAI) is a novel approach to characterize surface adsorption energy of nanomaterials that is the primary force behind nanoparticle aggregation, protein corona formation, and other complex interactions of nanomaterials within biological systems. Five quantitative nanodescriptors were obtained to represent the surface adsorption forces (hydrophobicity, hydrogen bond, polarity/polarizability, and lone-pair electrons) of the nanomaterial interaction with biological components. We have mapped the surface adsorption forces over 16 different nanomaterials. When the five-dimensional information of the nanodescriptors was reduced to two dimensions, the 16 nanomaterials were classified Into distinct clusters according their surface adsorption properties. BSAI nanodescriptors are Intrinsic properties of nanomaterials useful for quantitative structure-activity relationship (QSAR) model development. This Is the first success in quantitative characterization of the surface adsorption forces of nanomaterials in biological conditions, which could open a quantitative avenue in predictive nanomedicine development, risk assessment, and safety evaluation of nanomaterials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xia, Xin R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Monteiro-Riviere, Nancy A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Xuefeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiao, Lisong UNSPECIFIED UNSPECIFIED UNSPECIFIED Oldenberg, Steven J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fadeel, Bengt UNSPECIFIED UNSPECIFIED UNSPECIFIED Riviere, Jim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-486030
DOI:	10.1021/nn203303c
Journal or Publication Title:	ACS Nano
Volume:	5
Number:	11
Page Range:	S. 9074 - 9082
Date:	2011
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1936-086X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARBON NANOTUBES; PHYSICOCHEMICAL PROPERTIES; NANOPARTICLE SIZE; AGGREGATION; VALIDATION; ACTIVATION; FIBRINOGEN; TOXICITY; PROTEINS; RATES Multiple languages Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48603