Universität zu Köln

Reich, David, Patterson, Nick, Kircher, Martin ORCID: 0000-0001-9278-5471, Delfin, Frederick ORCID: 0000-0002-8201-0661, Nandineni, Madhusudan R., Pugach, Irina, Ko, Albert Min-Shan ORCID: 0000-0002-2096-1330, Ko, Ying-Chin, Jinam, Timothy A., Phipps, Maude E., Saitou, Naruya, Wollstein, Andreas, Kayser, Manfred, Paeaebo, Svante and Stoneking, Mark (2011). Denisova Admixture and the First Modern Human Dispersals into Southeast Asia and Oceania. Am. J. Hum. Genet., 89 (4). S. 516 - 529. CAMBRIDGE: CELL PRESS. ISSN 1537-6605

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Abstract

It has recently been shown that ancestors of New Guineans and Bougainville Islanders have inherited a proportion of their ancestry from Denisovans, an archaic hominin group from Siberia. However, only a sparse sampling of populations from Southeast Asia and Oceania were analyzed. Here, we quantify Denisova admixture in 33 additional populations from Asia and Oceania. Aboriginal Australians, Near Oceanians, Polynesians, Fijians, east Indonesians, and Mamanwa (a Negrito group from the Philippines) have all inherited genetic material from Denisovans, but mainland East Asians, western Indonesians, Jehai (a Negrito group from Malaysia), and Onge (a Negrito group from the Andaman Islands) have not. These results indicate that Denisova gene flow occurred into the common ancestors of New Guineans, Australians, and Mamanwa but not into the ancestors of the Jehai and Onge and suggest that relatives of present-day East Asians were not in Southeast Asia when the Denisova gene flow occurred. Our finding that descendants of the earliest inhabitants of Southeast Asia do not all harbor Denisova admixture is inconsistent with a history in which the Denisova interbreeding occurred in mainland Asia and then spread over Southeast Asia, leading to all its earliest modern human inhabitants. Instead, the data can be most parsimoniously explained if the Denisova gene flow occurred in Southeast Asia itself. Thus, archaic Denisovans must have lived over an extraordinarily broad geographic and ecological range, from Siberia to tropical Asia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reich, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Patterson, Nick UNSPECIFIED UNSPECIFIED UNSPECIFIED Kircher, Martin UNSPECIFIED orcid.org/0000-0001-9278-5471 UNSPECIFIED Delfin, Frederick UNSPECIFIED orcid.org/0000-0002-8201-0661 UNSPECIFIED Nandineni, Madhusudan R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pugach, Irina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ko, Albert Min-Shan UNSPECIFIED orcid.org/0000-0002-2096-1330 UNSPECIFIED Ko, Ying-Chin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jinam, Timothy A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Phipps, Maude E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saitou, Naruya UNSPECIFIED UNSPECIFIED UNSPECIFIED Wollstein, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kayser, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Paeaebo, Svante UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoneking, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-487416
DOI:	10.1016/j.ajhg.2011.09.005
Journal or Publication Title:	Am. J. Hum. Genet.
Volume:	89
Number:	4
Page Range:	S. 516 - 529
Date:	2011
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1537-6605
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Y-CHROMOSOME; NEW-GUINEA; GENETIC DIVERSITY; MTDNA; COLONIZATION; AUSTRALIANS; SETTLEMENT; JACKKNIFE; PACIFIC; ORIGINS Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48741