Reich, David, Patterson, Nick, Kircher, Martin ORCID: 0000-0001-9278-5471, Delfin, Frederick ORCID: 0000-0002-8201-0661, Nandineni, Madhusudan R., Pugach, Irina, Ko, Albert Min-Shan ORCID: 0000-0002-2096-1330, Ko, Ying-Chin, Jinam, Timothy A., Phipps, Maude E., Saitou, Naruya, Wollstein, Andreas, Kayser, Manfred, Paeaebo, Svante and Stoneking, Mark (2011). Denisova Admixture and the First Modern Human Dispersals into Southeast Asia and Oceania. Am. J. Hum. Genet., 89 (4). S. 516 - 529. CAMBRIDGE: CELL PRESS. ISSN 1537-6605

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Abstract

It has recently been shown that ancestors of New Guineans and Bougainville Islanders have inherited a proportion of their ancestry from Denisovans, an archaic hominin group from Siberia. However, only a sparse sampling of populations from Southeast Asia and Oceania were analyzed. Here, we quantify Denisova admixture in 33 additional populations from Asia and Oceania. Aboriginal Australians, Near Oceanians, Polynesians, Fijians, east Indonesians, and Mamanwa (a Negrito group from the Philippines) have all inherited genetic material from Denisovans, but mainland East Asians, western Indonesians, Jehai (a Negrito group from Malaysia), and Onge (a Negrito group from the Andaman Islands) have not. These results indicate that Denisova gene flow occurred into the common ancestors of New Guineans, Australians, and Mamanwa but not into the ancestors of the Jehai and Onge and suggest that relatives of present-day East Asians were not in Southeast Asia when the Denisova gene flow occurred. Our finding that descendants of the earliest inhabitants of Southeast Asia do not all harbor Denisova admixture is inconsistent with a history in which the Denisova interbreeding occurred in mainland Asia and then spread over Southeast Asia, leading to all its earliest modern human inhabitants. Instead, the data can be most parsimoniously explained if the Denisova gene flow occurred in Southeast Asia itself. Thus, archaic Denisovans must have lived over an extraordinarily broad geographic and ecological range, from Siberia to tropical Asia.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Reich, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patterson, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kircher, MartinUNSPECIFIEDorcid.org/0000-0001-9278-5471UNSPECIFIED
Delfin, FrederickUNSPECIFIEDorcid.org/0000-0002-8201-0661UNSPECIFIED
Nandineni, Madhusudan R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pugach, IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ko, Albert Min-ShanUNSPECIFIEDorcid.org/0000-0002-2096-1330UNSPECIFIED
Ko, Ying-ChinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jinam, Timothy A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phipps, Maude E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saitou, NaruyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wollstein, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kayser, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paeaebo, SvanteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoneking, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-487416
DOI: 10.1016/j.ajhg.2011.09.005
Journal or Publication Title: Am. J. Hum. Genet.
Volume: 89
Number: 4
Page Range: S. 516 - 529
Date: 2011
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1537-6605
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Y-CHROMOSOME; NEW-GUINEA; GENETIC DIVERSITY; MTDNA; COLONIZATION; AUSTRALIANS; SETTLEMENT; JACKKNIFE; PACIFIC; ORIGINSMultiple languages
Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48741

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