Grubert, Christiane, Hurlemann, Rene ORCID: 0000-0003-2628-565X, Bewernick, Bettina H., Kayser, Sarah, Hadrysiewicz, Barbara, Axmacher, Nikolai
ORCID: 0000-0002-0475-6492, Sturm, Volker and Schlaepfer, Thomas E.
(2011).
Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression: Effects of 12-month stimulation.
World J. Biol. Psychiatry, 12 (7).
S. 516 - 528.
ABINGDON:
TAYLOR & FRANCIS LTD.
ISSN 1814-1412
Abstract
Objectives. Deep brain stimulation (DBS) to the nucleus accumbens (NAcc-DBS) has antidepressant effects in patients suffering from treatment-resistant depression (TRD). However, limited information exists regarding the impact of NAcc-DBS on cognitive functioning. The aim of this study was to examine whether NAcc-DBS in patients with TRD has any cognitive effects. Methods. A comprehensive neuropsychological battery was administered to 10 patients with TRD before onset of bilateral NAcc-DBS and after 1 year of DBS stimulation. Neuropsychological testing covered the domains of attention, learning and memory, executive functions, visual perception, and language. Performance was analyzed at baseline and after 1 year of continuous DBS. Results. No evidence was found for cognitive decline following NAcc-DBS comparing test results after 1 year of NAcc-DBS with baseline. However, significantly improved cognitive performance on tests of attention, learning and memory, executive functions and visual perception was found. In addition, there was a general trend towards cognitive enhancement from below average to average performance. These procognitive effects were independent of the antidepressant effects of NAcc-DBS or changes in NAcc-DBS parameters. Conclusions. These results not only support cognitive safety of NAcc-DBS but also stress its beneficial role in augmenting cognitive performance in patients with TRD.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-488640 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.3109/15622975.2011.583940 | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | World J. Biol. Psychiatry | ||||||||||||||||||||||||||||||||||||
Volume: | 12 | ||||||||||||||||||||||||||||||||||||
Number: | 7 | ||||||||||||||||||||||||||||||||||||
Page Range: | S. 516 - 528 | ||||||||||||||||||||||||||||||||||||
Date: | 2011 | ||||||||||||||||||||||||||||||||||||
Publisher: | TAYLOR & FRANCIS LTD | ||||||||||||||||||||||||||||||||||||
Place of Publication: | ABINGDON | ||||||||||||||||||||||||||||||||||||
ISSN: | 1814-1412 | ||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||
Uncontrolled Keywords: |
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URI: | http://kups.ub.uni-koeln.de/id/eprint/48864 |
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