Pukrop, Ralf and Klosterkoetter, Joachim (2010). Neurocognitive Indicators of Clinical High-Risk States for Psychosis: A Critical Review of the Evidence. Neurotox. Res., 18 (3-4). S. 272 - 287. NEW YORK: SPRINGER. ISSN 1029-8428
Full text not available from this repository.Abstract
The present review investigates the empirical evidence from cross-sectional and long-term follow-up studies on neurocognitive indicators of an increased risk for developing schizophrenia spectrum psychoses in clinically defined high-risk samples. First, the investigations at the Cologne center for early recognition and intervention are briefly summarized and then integrated within the available literature. Thirty-two studies with original data could be identified by extensive literature search. Cross-sectional investigations of neurocognitive baseline assessments in high-risk samples with unknown conversion status have produced rather inconsistent results. Nevertheless, most convincing evidence could be collected for abnormal functioning in processing speed measures (digit symbol coding, Trailmaking Test-B, Stroop Color Naming), the Continuous Performance Test, verbal working memory measures, verbal memory and learning, and verbal fluency, though negative findings have also been reported in every instance. Moreover, high-risk subjects were found to perform both at the schizophrenia performance level and at a close to normal level. Longitudinal follow-up assessments provided predictive evidence with regard to psychosis conversion for measures of processing speed and of verbal memory and learning. However, a substantial number of negative findings does not allow for straight-forward conclusions. Finally, some reasons for inconsistent findings are discussed critically speculating on demographic differences, reliability and sample sizes, and conceptual imprecision in communicating results.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-493814 | ||||||||||||
DOI: | 10.1007/s12640-010-9191-1 | ||||||||||||
Journal or Publication Title: | Neurotox. Res. | ||||||||||||
Volume: | 18 | ||||||||||||
Number: | 3-4 | ||||||||||||
Page Range: | S. 272 - 287 | ||||||||||||
Date: | 2010 | ||||||||||||
Publisher: | SPRINGER | ||||||||||||
Place of Publication: | NEW YORK | ||||||||||||
ISSN: | 1029-8428 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/49381 |
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