Universität zu Köln

Mengele, Karin, Napieralski, Rudolf, Magdolen, Viktor, Reuning, Ute, Gkazepis, Apostolos, Sweep, Fred ORCID: 0000-0003-1103-3070, Bruenner, Nils, Foekens, John, Harbeck, Nadia and Schmittt, Manfred (2010). Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1. Expert Rev. Mol. Diagn., 10 (7). S. 947 - 963. OSLO: TAYLOR & FRANCIS AS. ISSN 1744-8352

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Abstract

In cancer, the serine protease urokinase-type plasminogen activator, its inhibitor (plasminogen activator inhibitor type-1) and the receptor (CD87), among other proteolytic factors, are involved in tumor cell dissemination and turnover of the extracellular matrix. Unsurprisingly, a battery of very uniform data, amassed since the end of the 1990s, has put these members of the plasminogen activation system into the forefront of prognostic/predictive cancer biomarkers relevant to predict the clinical course of cancer patients and their response to cancer therapy. The present review focuses on the molecular characteristics of the disease forecast biomarkers urokinase-type plasminogen activator and plasminogen activator inhibitor type-1, and techniques to quantitatively assess these cancer biomarkers, in the context of potential clinical application and personalized disease management.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mengele, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Napieralski, Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Magdolen, Viktor UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuning, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Gkazepis, Apostolos UNSPECIFIED UNSPECIFIED UNSPECIFIED Sweep, Fred UNSPECIFIED orcid.org/0000-0003-1103-3070 UNSPECIFIED Bruenner, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Foekens, John UNSPECIFIED UNSPECIFIED UNSPECIFIED Harbeck, Nadia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmittt, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495499
DOI:	10.1586/ERM.10.73
Journal or Publication Title:	Expert Rev. Mol. Diagn.
Volume:	10
Number:	7
Page Range:	S. 947 - 963
Date:	2010
Publisher:	TAYLOR & FRANCIS AS
Place of Publication:	OSLO
ISSN:	1744-8352
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLASMINOGEN-ACTIVATOR INHIBITOR-1; SQUAMOUS-CELL CARCINOMA; HUMAN BRAIN-TUMORS; HUMAN HEPATOCELLULAR-CARCINOMA; EPITHELIAL OVARIAN-CANCER; LYMPH-NODE METASTASIS; HUMAN BREAST-CANCER; GROWTH-FACTOR-BETA; RECEPTOR-RELATED PROTEIN; 3'-UTR T/C POLYMORPHISM Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49549