Mengele, Karin, Napieralski, Rudolf, Magdolen, Viktor, Reuning, Ute, Gkazepis, Apostolos, Sweep, Fred ORCID: 0000-0003-1103-3070, Bruenner, Nils, Foekens, John, Harbeck, Nadia and Schmittt, Manfred (2010). Characteristics of the level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1. Expert Rev. Mol. Diagn., 10 (7). S. 947 - 963. OSLO: TAYLOR & FRANCIS AS. ISSN 1744-8352

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Abstract

In cancer, the serine protease urokinase-type plasminogen activator, its inhibitor (plasminogen activator inhibitor type-1) and the receptor (CD87), among other proteolytic factors, are involved in tumor cell dissemination and turnover of the extracellular matrix. Unsurprisingly, a battery of very uniform data, amassed since the end of the 1990s, has put these members of the plasminogen activation system into the forefront of prognostic/predictive cancer biomarkers relevant to predict the clinical course of cancer patients and their response to cancer therapy. The present review focuses on the molecular characteristics of the disease forecast biomarkers urokinase-type plasminogen activator and plasminogen activator inhibitor type-1, and techniques to quantitatively assess these cancer biomarkers, in the context of potential clinical application and personalized disease management.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mengele, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Napieralski, RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Magdolen, ViktorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reuning, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gkazepis, ApostolosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sweep, FredUNSPECIFIEDorcid.org/0000-0003-1103-3070UNSPECIFIED
Bruenner, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foekens, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harbeck, NadiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmittt, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-495499
DOI: 10.1586/ERM.10.73
Journal or Publication Title: Expert Rev. Mol. Diagn.
Volume: 10
Number: 7
Page Range: S. 947 - 963
Date: 2010
Publisher: TAYLOR & FRANCIS AS
Place of Publication: OSLO
ISSN: 1744-8352
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PLASMINOGEN-ACTIVATOR INHIBITOR-1; SQUAMOUS-CELL CARCINOMA; HUMAN BRAIN-TUMORS; HUMAN HEPATOCELLULAR-CARCINOMA; EPITHELIAL OVARIAN-CANCER; LYMPH-NODE METASTASIS; HUMAN BREAST-CANCER; GROWTH-FACTOR-BETA; RECEPTOR-RELATED PROTEIN; 3'-UTR T/C POLYMORPHISMMultiple languages
PathologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/49549

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