Dadsena, Shashank ORCID: 0000-0002-0227-5900, Zollo, Cristiana and Garcia-Saez, Ana J. (2021). Mechanisms of mitochondrial cell death. Biochem. Soc. Trans., 49 (2). S. 663 - 675. LONDON: PORTLAND PRESS LTD. ISSN 1470-8752
Full text not available from this repository.Abstract
Mitochondria are double-membrane bound organelles that not only provide energy for intracellular metabolism, but also play a key role in the regulation of cell death. Mitochondrial outer membrane permeabilization (MOMP), allowing the release of inter-membrane space proteins like cytochrome c, is considered a point of no return in apoptosis. MOMP is controlled by the proteins of the B-cell lymphoma 2 (BCL-2) family, including pro-and anti-apoptotic members, whose balance determines the decision between cell death and survival. Other factors such as membrane lipid environment, membrane dynamics, and inter-organelle communications are also known to influence this process. MOMP and apoptosis have been acknowledged as immunologically silent. Remarkably, a growing body of evidence indicates that MOMP can engage in various pro-inflammatory signaling functions. In this mini-review, we discuss about our current knowledge on the mechanisms of mitochondrial apoptosis, as well as the involvement of mitochondria in other kinds of programmed cell death pathways.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-564047 | ||||||||||||||||
DOI: | 10.1042/BST20200522 | ||||||||||||||||
Journal or Publication Title: | Biochem. Soc. Trans. | ||||||||||||||||
Volume: | 49 | ||||||||||||||||
Number: | 2 | ||||||||||||||||
Page Range: | S. 663 - 675 | ||||||||||||||||
Date: | 2021 | ||||||||||||||||
Publisher: | PORTLAND PRESS LTD | ||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||
ISSN: | 1470-8752 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/56404 |
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