Universität zu Köln

Dadsena, Shashank ORCID: 0000-0002-0227-5900, Zollo, Cristiana and Garcia-Saez, Ana J. (2021). Mechanisms of mitochondrial cell death. Biochem. Soc. Trans., 49 (2). S. 663 - 675. LONDON: PORTLAND PRESS LTD. ISSN 1470-8752

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Abstract

Mitochondria are double-membrane bound organelles that not only provide energy for intracellular metabolism, but also play a key role in the regulation of cell death. Mitochondrial outer membrane permeabilization (MOMP), allowing the release of inter-membrane space proteins like cytochrome c, is considered a point of no return in apoptosis. MOMP is controlled by the proteins of the B-cell lymphoma 2 (BCL-2) family, including pro-and anti-apoptotic members, whose balance determines the decision between cell death and survival. Other factors such as membrane lipid environment, membrane dynamics, and inter-organelle communications are also known to influence this process. MOMP and apoptosis have been acknowledged as immunologically silent. Remarkably, a growing body of evidence indicates that MOMP can engage in various pro-inflammatory signaling functions. In this mini-review, we discuss about our current knowledge on the mechanisms of mitochondrial apoptosis, as well as the involvement of mitochondria in other kinds of programmed cell death pathways.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dadsena, Shashank UNSPECIFIED orcid.org/0000-0002-0227-5900 UNSPECIFIED Zollo, Cristiana UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Saez, Ana J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-564047
DOI:	10.1042/BST20200522
Journal or Publication Title:	Biochem. Soc. Trans.
Volume:	49
Number:	2
Page Range:	S. 663 - 675
Date:	2021
Publisher:	PORTLAND PRESS LTD
Place of Publication:	LONDON
ISSN:	1470-8752
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; ENDOPLASMIC-RETICULUM; INDUCED APOPTOSIS; MEMBRANE-ACTIVITY; PROAPOPTOTIC BAX; CONTACT SITES; INFLAMMASOME; ER; PROTEINS; BAX/BAK Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56404