Hommen, Franziska ORCID: 0000-0002-1612-6973, Bilican, Saygin
ORCID: 0000-0001-9448-6504 and Vilchez, David
ORCID: 0000-0002-0801-0743
(2022).
Protein clearance strategies for disease intervention.
J. Neural Transm., 129 (2).
S. 141 - 173.
WIEN:
SPRINGER WIEN.
ISSN 1435-1463
Abstract
Protein homeostasis, or proteostasis, is essential for cell function and viability. Unwanted, damaged, misfolded and aggregated proteins are degraded by the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway. Growing evidence indicates that alterations in these major proteolytic mechanisms lead to a demise in proteostasis, contributing to the onset and development of distinct diseases. Indeed, dysregulation of the UPS or autophagy is linked to several neurodegenerative, infectious and inflammatory disorders as well as cancer. Thus, modulation of protein clearance pathways is a promising approach for therapeutics. In this review, we discuss recent findings and open questions on how targeting proteolytic mechanisms could be applied for disease intervention.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
|
||||||||||||||||
URN: | urn:nbn:de:hbz:38-569452 | ||||||||||||||||
DOI: | 10.1007/s00702-021-02431-y | ||||||||||||||||
Journal or Publication Title: | J. Neural Transm. | ||||||||||||||||
Volume: | 129 | ||||||||||||||||
Number: | 2 | ||||||||||||||||
Page Range: | S. 141 - 173 | ||||||||||||||||
Date: | 2022 | ||||||||||||||||
Publisher: | SPRINGER WIEN | ||||||||||||||||
Place of Publication: | WIEN | ||||||||||||||||
ISSN: | 1435-1463 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
Uncontrolled Keywords: |
|
||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/56945 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
![]() |
View Item |