Universität zu Köln

Quhal, Fahad ORCID: 0000-0002-8163-6953, Rajwa, Pawel, Mori, Keiic, Laukhtina, Ekaterina, Grossmann, Nico, Schuettfort, Victor M., Koenig, Frederik, Aydh, Abdulmajeed, Motlagh, Reza S., Katayama, Satoshi, Mostafai, Hadi, Pradere, Benjamin, Marra, Giancarlo, Gontero, Paolo, Mathieu, Romain, Karakiewicz, Pierre I., Briganti, Alberto, Shariat, Shahrokh F. and Heidenreich, Axel (2021). The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer. Prostate, 81 (11). S. 765 - 772. HOBOKEN: WILEY. ISSN 1097-0045

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Abstract

Purpose To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP). Material and Methods We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of the number of removed lymph nodes (RLNs) and the number of positive lymph nodes (PLNs) on biochemical recurrence (BCR)-free survival, metastases free survival, and overall survival (OS) was tested in multivariable Cox regression analyses. Results About 334 patients underwent SRP and pelvic lymph node dissection (PLND). Lymph node involvement was associated with increased risk of BCR (p < .001), metastasis (p < .001), and overall mortality (p = .006). In a multivariable Cox regression analysis, an increased number of RLNs significantly lowered the risk of BCR (hazard ratio [HR] 0.96, p = .01). In patients with positive lymph nodes, a higher number of RLNs and a lower number of PLNs were associated with improved freedom from BCR (HR 0.89, p = .001 and HR 1.34, p = .008, respectively). At a median follow-up of 23.9 months (interquartile range, 4.7-37.7), neither the number of RLNs nor the number of PLNs were associated with OS (p = .69 and p = .34, respectively). Conclusion Pathologic lymph node involvement increased the risk of BCR, metastasis and overall mortality in radiation-recurrent PCa patients undergoing SRP. The risk of BCR decreased steadily with a higher number of RLNs during SRP. Further research is needed to support this conclusion and develop a precise therapeutic adjuvant strategy based on the number of RLNs and PLNs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Quhal, Fahad UNSPECIFIED orcid.org/0000-0002-8163-6953 UNSPECIFIED Rajwa, Pawel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mori, Keiic UNSPECIFIED UNSPECIFIED UNSPECIFIED Laukhtina, Ekaterina UNSPECIFIED UNSPECIFIED UNSPECIFIED Grossmann, Nico UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuettfort, Victor M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Frederik UNSPECIFIED UNSPECIFIED UNSPECIFIED Aydh, Abdulmajeed UNSPECIFIED UNSPECIFIED UNSPECIFIED Motlagh, Reza S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Katayama, Satoshi UNSPECIFIED UNSPECIFIED UNSPECIFIED Mostafai, Hadi UNSPECIFIED UNSPECIFIED UNSPECIFIED Pradere, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Marra, Giancarlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Gontero, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathieu, Romain UNSPECIFIED UNSPECIFIED UNSPECIFIED Karakiewicz, Pierre I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Briganti, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Shariat, Shahrokh F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-605823
DOI:	10.1002/pros.24173
Journal or Publication Title:	Prostate
Volume:	81
Number:	11
Page Range:	S. 765 - 772
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0045
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SURVIVAL; THERAPY; FAILURE; RADIOTHERAPY; MEN; PATTERNS; OUTCOMES; SURGERY Multiple languages Endocrinology & Metabolism; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60582