Hackl, Agnes and Weber, Lutz T.
(2025).
The Ca2+-actin-cytoskeleton axis in podocytes is an important, non-immunologic target of immunosuppressive therapy in proteinuric kidney diseases.
Pediatric Nephrology, 40 (9).
pp. 2729-2739.
Springer Nature.
ISSN 0931-041X
![[thumbnail of s00467-025-06670-z.pdf]](http://kups.ub.uni-koeln.de/style/images/fileicons/application_pdf.png "s00467-025-06670-z.pdf") |
PDF
s00467-025-06670-z.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (1MB) |
Abstract
The integrity of the filtration barrier of the kidney relies on the proper composition of podocyte interdigitating foot processes. Their architecture is supported by a complex actin-cytoskeleton. Following podocyte stress or injury, podocytes encounter structural changes, including rearrangement of the actin network and subsequent effacement of the foot processes. Immunosuppressive drugs, which are currently used as treatment in proteinuric kidney diseases, have been shown to exert not only immune-mediated effects. This review will focus on the direct effects of glucocorticoids, cyclosporine A, tacrolimus, mycophenolate mofetil, and rituximab on podocytes by regulation of Ca 2+ ion channels and consecutive downstream signaling which prevent cytoskeletal rearrangements and ultimately proteinuria. In addition, the efficacy of these drugs in genetic nephrotic syndrome will be discussed
| Item Type: | Article |
| Creators: | Creators Email ORCID ORCID Put Code Hackl, Agnes UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Lutz T. UNSPECIFIED UNSPECIFIED UNSPECIFIED |
| URN: | urn:nbn:de:hbz:38-797825 |
| Identification Number: | 10.1007/s00467-025-06670-z |
| Journal or Publication Title: | Pediatric Nephrology |
| Volume: | 40 |
| Number: | 9 |
| Page Range: | pp. 2729-2739 |
| Number of Pages: | 11 |
| Date: | 25 September 2025 |
| Publisher: | Springer Nature |
| ISSN: | 0931-041X |
| Language: | English |
| Faculty: | Faculty of Medicine |
| Divisions: | Faculty of Medicine > Kinder- und Jugendmedizin > Klinik und Poliklinik für Kinder- und Jugendmedizin |
| Subjects: | Medical sciences Medicine |
| ['eprint_fieldname_oa_funders' not defined]: | Publikationsfonds UzK |
| Refereed: | Yes |
| URI: | http://kups.ub.uni-koeln.de/id/eprint/79782 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
 |
View Item |