Universität zu Köln

Journal Article

Dietlein, Felix, Kalb, Bastian, Jokic, Mladen, Noll, Elisa M., Strong, Alexander, Tharun, Lars, Ozretic, Luka, Kuenstlinger, Helen, Kambartel, Kato, Randerath, Winfried J., Juengst, Christian, Schmitt, Anna, Torgovnick, Alessandro, Richters, Andre, Rauh, Daniel ORCID: 0000-0002-1970-7642, Siedek, Florian, Persigehl, Thorsten, Mauch, Cornelia, Bartkova, Jirina, Bradley, Allan ORCID: 0000-0002-2349-8839, Sprick, Martin R. ORCID: 0000-0001-9691-7574, Trumpp, Andreas ORCID: 0000-0002-6212-3466, Rad, Roland, Saur, Dieter ORCID: 0000-0001-5874-0210, Bartek, Jiri, Wolf, Juergen, Buettner, Reinhard, Thomas, Roman K. and Reinhardt, H. Christian (2015). A Synergistic Interaction between Chk1-and MK2 Inhibitors in KRAS-Mutant Cancer. Cell, 162 (1). S. 146 - 160. CAMBRIDGE: CELL PRESS. ISSN 1097-4172

Engel, Julian, Richters, Andre, Getlik, Matthaeus, Tomassi, Stefano, Keul, Marina, Termathe, Martin ORCID: 0000-0002-5618-4633, Lategahn, Jonas ORCID: 0000-0001-5993-7082, Becker, Christian, Mayer-Wrangowski, Svenja, Gruetter, Christian, Uhlenbrock, Niklas ORCID: 0000-0002-4489-9535, Kruell, Jasmin, Schaumann, Niklas, Eppmann, Simone, Kibies, Patrick, Hoffgaard, Franziska, Heil, Jochen, Menninger, Sascha, Ortiz-Cuaran, Sandra, Heuckmann, Johannes M., Tinnefeld, Verena, Zahedi, Rene P., Sos, Martin L., Schultz-Fademrecht, Carsten, Thomas, Roman K., Kast, Stefan M. and Rauh, Daniel ORCID: 0000-0002-1970-7642 (2015). Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach. J. Med. Chem., 58 (17). S. 6844 - 6864. WASHINGTON: AMER CHEMICAL SOC. ISSN 1520-4804

Fang, Zhizhou, Simard, Jeffrey R., Plenker, Dennis, Nguyen, Hoang D., Wolle, Patrik, Baumeister, Stefan and Rauh, Daniel ORCID: 0000-0002-1970-7642 (2015). Discovery of Inter-Domain Stabilizers-A Novel Assay System for Allosteric Akt Inhibitors. ACS Chem. Biol., 10 (1). S. 279 - 289. WASHINGTON: AMER CHEMICAL SOC. ISSN 1554-8937

Heuckmann, Johannes M., Hoelzel, Michael, Sos, Martin L., Heynck, Stefanie, Balke-Want, Hyatt, Koker, Mirjam, Peifer, Martin ORCID: 0000-0002-5243-5503, Weiss, Jonathan, Lovly, Christine M., Gruetter, Christian, Rauh, Daniel ORCID: 0000-0002-1970-7642, Pao, William and Thomas, Roman K. (2011). ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors. Clin. Cancer Res., 17 (23). S. 7394 - 7402. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1078-0432

Heuckmann, Johannes M., Rauh, Daniel ORCID: 0000-0002-1970-7642 and Thomas, Roman K. (2012). Epidermal Growth Factor Receptor (EGFR) Signaling and Covalent EGFR Inhibition in Lung Cancer. J. Clin. Oncol., 30 (27). S. 3417 - 3421. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. ISSN 0732-183X

Lategahn, Jonas, Tumbrink, Hannah L., Schultz-Fademrecht, Carsten, Heimsoeth, Alena, Werr, Lisa ORCID: 0000-0002-3697-4136, Niggenaber, Janina, Keul, Marina, Parmaksiz, Fatma ORCID: 0009-0003-3771-7128, Baumann, Matthias, Menninger, Sascha, Zent, Eldar, Landel, Ina, Weisner, Joern, Jeyakumar, Kirujan ORCID: 0000-0002-0184-6775, Heyden, Leonie, Russ, Nicole, Mueller, Fabienne, Lorenz, Carina, Braegelmann, Johannes, Spille, Inga, Grabe, Tobias ORCID: 0000-0002-8287-1971, Mueller, Matthias P., Heuckmann, Johannes M., Klebl, Bert M., Nussbaumer, Peter, Sos, Martin L. and Rauh, Daniel (2022). Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J. Med. Chem., 65 (9). S. 6643 - 6656. WASHINGTON: AMER CHEMICAL SOC. ISSN 1520-4804

Malchers, Florian, Dietlein, Felix, Schottle, Jakob, Lu, Xin, Nogova, Lucia, Albus, Kerstin, Fernandez-Cuesta, Lynnette ORCID: 0000-0002-0724-6703, Heuckmann, Johannes M., Gautschi, Oliver, Diebold, Joachim, Plenker, Dennis, Gardizi, Masyar, Er, Matthias Scheffl, Bos, Marc, Seidel, Danila, Leenders, Frauke, Richters, Andre, Peifer, Martin ORCID: 0000-0002-5243-5503, Florin, Alexandra, Mainkar, Prathama S., Karre, Nagaraju, Chandrasekhar, Srivari, George, Julie, Silling, Steffi, Rauh, Daniel ORCID: 0000-0002-1970-7642, Zander, Thomas, Ullrich, Roland T., Reinhardt, H. Christian, Ringeisen, Francois, Buettner, Reinhard, Heukamp, Lukas C., Wolf, Juergen and Thomas, Roman K. (2014). Cell-Autonomous and Non-Cell-Autonomous Mechanisms of Transformation by Amplified FGFR1 in Lung Cancer. Cancer Discov., 4 (2). S. 246 - 258. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 2159-8290

Peifer, Martin ORCID: 0000-0002-5243-5503, Fernandez-Cuesta, Lynnette ORCID: 0000-0002-0724-6703, Sos, Martin L., George, Julie, Seidel, Danila ORCID: 0000-0003-4388-3117, Kasper, Lawryn H., Plenker, Dennis, Leenders, Frauke, Sun, Ruping, Zander, Thomas, Menon, Roopika, Koker, Mirjam, Dahmen, Ilona, Mueller, Christian, Di Cerbo, Vincenzo ORCID: 0000-0002-2920-1274, Schildhaus, Hans-Ulrich, Altmueller, Janine, Baessmann, Ingelore, Becker, Christian, de Wilde, Bram, Vandesompele, Jo ORCID: 0000-0001-6274-0184, Boehm, Diana, Ansen, Sascha, Gabler, Franziska, Wilkening, Ines, Heynck, Stefanie, Heuckmann, Johannes M., Lu, Xin, Carter, Scott L., Cibulskis, Kristian, Banerji, Shantanu, Getz, Gad, Park, Kwon-Sik, Rauh, Daniel ORCID: 0000-0002-1970-7642, Gruetter, Christian, Fischer, Matthias, Pasqualucci, Laura, Wright, Gavin ORCID: 0000-0002-7000-9305, Wainer, Zoe, Russell, Prudence, Petersen, Iver, Chen, Yuan, Stoelben, Erich, Ludwig, Corinna, Schnabel, Philipp, Hoffmann, Hans, Muley, Thomas, Brockmann, Michael, Engel-Riedel, Walburga, Muscarella, Lucia A., Fazio, Vito M., Groen, Harry, Timens, Wim ORCID: 0000-0002-4146-6363, Sietsma, Hannie, Thunnissen, Erik ORCID: 0000-0001-5355-8508, Smit, Egbert, Heideman, Danielle A. M., Snijders, Peter J. F., Cappuzzo, Federico, Ligorio, Claudia, Damiani, Stefania, Field, John, Solberg, Steinar, Brustugun, Odd Terje, Lund-Iversen, Marius, Saenger, Joerg, Clement, Joachim H. ORCID: 0000-0002-6601-2456, Soltermann, Alex, Moch, Holger, Weder, Walter, Solomon, Benjamin, Soria, Jean-Charles, Validire, Pierre, Besse, Benjamin ORCID: 0000-0001-5090-8189, Brambilla, Elisabeth, Brambilla, Christian, Lantuejoul, Sylvie, Lorimier, Philippe, Schneider, Peter M. ORCID: 0000-0003-0744-2349, Hallek, Michael, Pao, William, Meyerson, Matthew ORCID: 0000-0002-9133-8108, Sage, Julien, Shendure, Jay ORCID: 0000-0002-1516-1865, Schneider, Robert, Buettner, Reinhard, Wolf, Juergen, Nuernberg, Peter, Perner, Sven, Heukamp, Lukas C., Brindle, Paul K., Haas, Stefan ORCID: 0000-0003-3418-3688 and Thomas, Roman K. (2012). Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nature Genet., 44 (10). S. 1104 - 1113. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1718

Richters, Andre, Basu, Debjit, Engel, Julian, Ercanoglu, Meryem S., Balke-Want, Hyatt, Tesch, Roberta, Thomas, Roman K. and Rauh, Daniel ORCID: 0000-0002-1970-7642 (2015). Identification and Further Development of Potent TBK1 Inhibitors. ACS Chem. Biol., 10 (1). S. 289 - 299. WASHINGTON: AMER CHEMICAL SOC. ISSN 1554-8937

Schoettle, Jakob, Chatterjee, Sampurna, Volz, Caroline, Siobal, Maike, Florin, Alexandra, Rokitta, Dennis, Hinze, Yvonne, Dietlein, Felix, Plenker, Dennis, Koenig, Katharina, Albus, Kerstin, Heuckmann, Johannes M., Rauh, Daniel ORCID: 0000-0002-1970-7642, Franz, Thomas, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Fuhr, Uwe, Heukamp, Lukas C. and Ullrich, Roland T. (2015). Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer. Oncotarget, 6 (36). S. 38458 - 38469. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

Sos, Martin L., Dietlein, Felix, Peifer, Martin ORCID: 0000-0002-5243-5503, Schoettle, Jakob, Balke-Want, Hyatt, Mueller, Christian, Koker, Mirjam, Richters, Andre, Heynck, Stefanie, Malchers, Florian, Heuckmann, Johannes M., Seidel, Danila, Eyers, Patrick A., Ullrich, Roland T., Antonchick, Andrey P., Vintonyak, Viktor V., Schneider, Peter M. ORCID: 0000-0003-0744-2349, Ninomiya, Takashi, Waldmann, Herbert ORCID: 0000-0002-9606-7247, Buettner, Reinhard, Rauh, Daniel ORCID: 0000-0002-1970-7642, Heukamp, Lukas C. and Thomas, Roman K. (2012). A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc. Natl. Acad. Sci. U. S. A., 109 (42). S. 17034 - 17040. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

Tueckmantel, Sandra, Greul, Joerg N., Janning, Petra, Brockmeyer, Andreas, Gruetter, Christian, Simard, Jeffrey R., Gutbrod, Oliver, Beck, Michael E., Tietjen, Klaus, Rauh, Daniel ORCID: 0000-0002-1970-7642 and Schreier, Peter H. (2011). Identification of Ustilago maydis Aurora Kinase As a Novel Antifungal Target. ACS Chem. Biol., 6 (9). S. 926 - 934. WASHINGTON: AMER CHEMICAL SOC. ISSN 1554-8937

Volz, Caroline, Breid, Sara, Selenz, Carolin, Zaplatina, Alina, Golfmann, Kristina, Meder, Lydia, Dietlein, Felix, Borchmann, Sven, Chatterjee, Sampurna, Siobal, Maike, Schoettle, Jakob, Florin, Alexandra, Koker, Mirjam, Nill, Marieke, Ozretic, Luka, Uhlenbrock, Niklas, Smith, Steven, Buettner, Reinhard, Miao, Hui, Wang, Bingcheng, Reinhardt, H. Christian, Rauh, Daniel, Hallek, Michael, Acker-Palmer, Amparo, Heukamp, Lukas C. and Ullrich, Roland T. (2020). Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC. Cell Reports, 31 (4). CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Weiss, Jonathan, Sos, Martin L., Seidel, Danila, Peifer, Martin ORCID: 0000-0002-5243-5503, Zander, Thomas, Heuckmann, Johannes M., Ullrich, Roland T., Menon, Roopika, Maier, Sebastian, Soltermann, Alex, Moch, Holger, Wagener, Patrick, Fischer, Florian, Heynck, Stefanie, Koker, Mirjam, Schoettle, Jakob, Leenders, Frauke, Gabler, Franziska, Dabow, Ines, Querings, Silvia, Heukamp, Lukas C., Balke-Want, Hyatt, Ansen, Sascha, Rauh, Daniel ORCID: 0000-0002-1970-7642, Baessmann, Ingelore, Altmueller, Janine, Wainer, Zoe, Conron, Matthew, Wright, Gavin ORCID: 0000-0002-7000-9305, Russell, Prudence, Solomon, Ben, Brambilla, Elisabeth, Brambilla, Christian, Lorimier, Philippe, Sollberg, Steinar, Brustugun, Odd Terje, Engel-Riedel, Walburga, Ludwig, Corinna, Petersen, Iver, Saenger, Joerg, Clement, Joachim, Groen, Harry, Timens, Wim ORCID: 0000-0002-4146-6363, Sietsma, Hannie, Thunnissen, Erik ORCID: 0000-0001-5355-8508, Smit, Egbert, Heideman, Danielle, Cappuzzo, Federico, Ligorio, Claudia, Damiani, Stefania, Hallek, Michael, Beroukhim, Rameen, Pao, William, Klebl, Bert, Baumann, Matthias, Buettner, Reinhard, Ernestus, Karen, Stoelben, Erich, Wolf, Juergen, Nuernberg, Peter, Perner, Sven and Thomas, Roman K. (2010). Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer. Sci. Transl. Med., 2 (62). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1946-6242