Universität zu Köln

Hermanns, Thomas ORCID: 0000-0001-5350-7479 and Hofmann, Kay (2019). Bacterial DUBs: deubiquitination beyond the seven classes. Biochem. Soc. Trans., 47. S. 1857 - 1867. LONDON: PORTLAND PRESS LTD. ISSN 1470-8752

Full text not available from this repository.

Abstract

Protein ubiquitination is a posttranslational modification that regulates many aspects of cellular life, including proteostasis, vesicular trafficking, DNA repair and NF-kappa B activation. By directly targeting intracellular bacteria or bacteria-containing vacuoles to the lysosome, ubiquitination is also an important component of cell-autonomous immunity. Not surprisingly, several pathogenic bacteria encode deubiquitinases (DUBs) and use them as secreted effectors that prevent ubiquitination of bacterial components. A systematic overview of known bacterial DUBs, including their cleavage specificities and biological roles, suggests multiple independent acquisition events from host-encoded DUBs and other proteases. The widely used classification of DUBs into seven well-defined families should only be applied to eukaryotic DUBs, since several bacterial DUBs do not follow this classification.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hermanns, Thomas UNSPECIFIED orcid.org/0000-0001-5350-7479 UNSPECIFIED Hofmann, Kay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125223
DOI:	10.1042/BST20190526
Journal or Publication Title:	Biochem. Soc. Trans.
Volume:	47
Page Range:	S. 1857 - 1867
Date:	2019
Publisher:	PORTLAND PRESS LTD
Place of Publication:	LONDON
ISSN:	1470-8752
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NF-KAPPA-B; EFFECTOR XOPD TARGETS; ALPHA UBIQUITINATION; AUTOPHAGY; YOPJ; TRANSCRIPTION; SPECIFICITY; SUPPRESSION; ACTIVATION; PHAGOSOME Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12522