Thanarajah, Sharmili Edwin, Backes, Heiko, DiFeliceantonio, Alexandra G., Albus, Kerstin, Cremer, Anna Lena, Hanssen, Ruth, Lippert, Rachel N., Cornely, Oliver A., Small, Dana M., Bruening, Jens C. and Tittgemeyer, Marc (2019). Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metab., 29 (3). S. 695 - 711. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

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Abstract

Pleasant taste and nutritional value guide food selection behavior. Here, orosensory features of food may be secondary to its nutritional value in underlying reinforcement, but it is unclear how the brain encodes the reward value of food. Orosensory and peripheral physiological signals may act together on dopaminergic circuits to drive food intake. We combined fMRI and a novel [11C]raclopride PET method to assess systems-level activation and dopamine release in response to palatable food intake in humans. We identified immediate orosensory and delayed post-ingestive dopamine release. Both responses recruit segregated brain regions: specialized integrative pathways and higher cognitive centers. Furthermore, we identified brain areas where dopamine release reflected the subjective desire to eat. Immediate dopamine release in these wanting-related regions was inversely correlated with, and presumably inhibited, post-ingestive release in the dorsal striatum. Our results highlight the role of brain and periphery in interacting to reinforce food intake in humans.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Thanarajah, Sharmili EdwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Backes, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
DiFeliceantonio, Alexandra G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albus, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cremer, Anna LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanssen, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lippert, Rachel N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Small, Dana M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruening, Jens C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tittgemeyer, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-154192
DOI: 10.1016/j.cmet.2018.12.006
Journal or Publication Title: Cell Metab.
Volume: 29
Number: 3
Page Range: S. 695 - 711
Date: 2019
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1932-7420
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DORSAL STRIATUM; ACCUMBENS DOPAMINE; GUSTATORY CORTEX; IN-VIVO; REWARD; TASTE; BRAIN; RESPONSES; FAT; ORGANIZATIONMultiple languages
Cell Biology; Endocrinology & MetabolismMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15419

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