Universität zu Köln

Thanarajah, Sharmili Edwin ORCID: 0000-0003-3608-1474, Backes, Heiko, DiFeliceantonio, Alexandra G. ORCID: 0000-0002-7155-6060, Albus, Kerstin ORCID: 0000-0003-1124-4310, Cremer, Anna Lena, Hanssen, Ruth ORCID: 0000-0002-7283-9302, Lippert, Rachel N. ORCID: 0000-0002-6905-2234, Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Small, Dana M. ORCID: 0000-0001-7363-1100, Bruening, Jens C. and Tittgemeyer, Marc ORCID: 0000-0001-5072-2149 (2019). Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metab., 29 (3). S. 695 - 711. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

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Abstract

Pleasant taste and nutritional value guide food selection behavior. Here, orosensory features of food may be secondary to its nutritional value in underlying reinforcement, but it is unclear how the brain encodes the reward value of food. Orosensory and peripheral physiological signals may act together on dopaminergic circuits to drive food intake. We combined fMRI and a novel [11C]raclopride PET method to assess systems-level activation and dopamine release in response to palatable food intake in humans. We identified immediate orosensory and delayed post-ingestive dopamine release. Both responses recruit segregated brain regions: specialized integrative pathways and higher cognitive centers. Furthermore, we identified brain areas where dopamine release reflected the subjective desire to eat. Immediate dopamine release in these wanting-related regions was inversely correlated with, and presumably inhibited, post-ingestive release in the dorsal striatum. Our results highlight the role of brain and periphery in interacting to reinforce food intake in humans.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thanarajah, Sharmili Edwin UNSPECIFIED orcid.org/0000-0003-3608-1474 UNSPECIFIED Backes, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED DiFeliceantonio, Alexandra G. UNSPECIFIED orcid.org/0000-0002-7155-6060 UNSPECIFIED Albus, Kerstin UNSPECIFIED orcid.org/0000-0003-1124-4310 UNSPECIFIED Cremer, Anna Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanssen, Ruth UNSPECIFIED orcid.org/0000-0002-7283-9302 UNSPECIFIED Lippert, Rachel N. UNSPECIFIED orcid.org/0000-0002-6905-2234 UNSPECIFIED Cornely, Oliver A. UNSPECIFIED orcid.org/0000-0001-9599-3137 UNSPECIFIED Small, Dana M. UNSPECIFIED orcid.org/0000-0001-7363-1100 UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED orcid.org/0000-0001-5072-2149 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-154192
DOI:	10.1016/j.cmet.2018.12.006
Journal or Publication Title:	Cell Metab.
Volume:	29
Number:	3
Page Range:	S. 695 - 711
Date:	2019
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1932-7420
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Sonstiges > Zentrum für Versorgungsforschung Köln
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language DORSAL STRIATUM; ACCUMBENS DOPAMINE; GUSTATORY CORTEX; IN-VIVO; REWARD; TASTE; BRAIN; RESPONSES; FAT; ORGANIZATION Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15419