Universität zu Köln

Stark, Christina, Duran, Ibrahim ORCID: 0000-0003-4044-8822, Martakis, Kyriakos ORCID: 0000-0003-3982-0914, Spiess, Karoline, Semler, Oliver ORCID: 0000-0003-0029-7556 and Schoenau, Eckhard (2020). Effect of Long-Term Repeated Interval Rehabilitation on the Gross Motor Function Measure in Children with Cerebral Palsy. Neuropediatrics, 51 (6). S. 407 - 417. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-1899

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Abstract

Background The efficacy of interventions for cerebral palsy (CP) has been frequently investigated with inconclusive results and motor function measured by the Gross Motor Function Measure (GMFM-66) is common. Objective In this observational analysis, we quantify the GMFM-66 change scores of the second and third year of a multimodal rehabilitation program (interval rehabilitation including home-based, vibration-assisted training) in children with CP. Methods The study was a retrospective analysis of children with CP (2-13 years) participating for a second ( n =262) and third year ( n =86) in the rehabilitation program with GMFM-66 scores at start (M0), after 4 months (M4) of intensive training, and after 8 months of follow-up (M12). A method was previously developed to differentiate between possible treatment effects and expected development under standard of care for GMFM-66 scores using Cohen's d effect size (ES; size of difference). Results After the treatment phase of 4 months (M4) in the second year, 125 of 262 children were responder (ES >= 0.2) and 137 children nonresponder (ES<0.2); mean ES for nonresponder was -0.212 (trivial) and for responder 0.836 (large). After M4 in the third year, 43 children of 86 were responder (ES=0.881 [large]) and 43 nonresponder (ES=-0.124 [trivial]). Discussion and Conclusion Repeated rehabilitation shows a large additional treatment effect to standard of care in 50% of children which is likely due to the intervention, because in the follow-up period (standard of care), no additional treatment effect was observed and the children followed their expected development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stark, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Duran, Ibrahim UNSPECIFIED orcid.org/0000-0003-4044-8822 UNSPECIFIED Martakis, Kyriakos UNSPECIFIED orcid.org/0000-0003-3982-0914 UNSPECIFIED Spiess, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Semler, Oliver UNSPECIFIED orcid.org/0000-0003-0029-7556 UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-314784
DOI:	10.1055/s-0040-1715489
Journal or Publication Title:	Neuropediatrics
Volume:	51
Number:	6
Page Range:	S. 407 - 417
Date:	2020
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-1899
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WHOLE-BODY VIBRATION; LONGITUDINAL DEVELOPMENT; VALIDATION Multiple languages Clinical Neurology; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31478