Ballantyne, Kaye N., Ralf, Arwin, Aboukhalid, Rachid, Achakzai, Niaz M. ORCID: 0000-0002-8872-6046, Anjos, Maria J., Ayub, Qasim ORCID: 0000-0003-3291-0917, Balazic, Joze, Ballantyne, Jack, Ballard, David J., Berger, Burkhard, Bobillo, Cecilia, Bouabdellah, Mehdi, Burri, Helen, Capal, Tomas, Caratti, Stefano ORCID: 0000-0002-8876-9724, Cardenas, Jorge, Cartault, Francois, Carvalho, Elizeu F., Carvalho, Monica, Cheng, Baowen, Coble, Michael D., Comas, David ORCID: 0000-0002-5075-0956, Corach, Daniel, D'Amato, Maria E., Davison, Sean, de Knijff, Peter ORCID: 0000-0002-0899-771X, De Ungria, Maria Corazon A., Decorte, Ronny, Dobosz, Tadeusz ORCID: 0000-0003-0413-9109, Dupuy, Berit M., Elmrghni, Samir, Gliwinski, Mateusz, Gomes, Sara C., Grol, Laurens, Haas, Cordula ORCID: 0000-0001-8122-1427, Hanson, Erin, Henke, Juergen, Henke, Lotte, Herrera-Rodriguez, Fabiola, Hill, Carolyn R., Holmlund, Gunilla, Honda, Katsuya, Immel, Uta-Dorothee, Inokuchi, Shota, Jobling, Mark A., Kaddura, Mahmoud, Kim, Jong S., Kim, Soon H., Kim, Wook, King, Turi E., Klausriegler, Eva, Kling, Daniel, Kovacevic, Lejla, Kovatsi, Leda, Krajewski, Pawel, Kravchenko, Sergey, Larmuseau, Maarten H. D., Lee, Eun Young, Lessig, Ruediger, Livshits, Ludmila A., Marjanovic, Damir ORCID: 0000-0002-7472-4525, Minarik, Marek ORCID: 0000-0002-0615-6116, Mizuno, Natsuko, Moreira, Helena, Morling, Niels ORCID: 0000-0002-9463-5087, Mukherjee, Meeta, Munier, Patrick, Nagaraju, Javaregowda, Neuhuber, Franz, Nie, Shengjie, Nilasitsataporn, Premlaphat, Nishi, Takeki ORCID: 0000-0002-6582-097X, Oh, Hye H., Olofsson, Jill ORCID: 0000-0002-9527-6573, Onofri, Valerio ORCID: 0000-0002-1294-1444, Palo, Jukka U., Pamjav, Horolma, Parson, Walther ORCID: 0000-0002-5692-2392, Petlach, Michal, Phillips, Christopher ORCID: 0000-0002-9601-0128, Ploski, Rafal ORCID: 0000-0001-6286-5526, Prasad, Samayamantri P. R., Primorac, Dragan, Purnomo, Gludhug A., Purps, Josephine, Rangel-Villalobos, Hector, Rebala, Krzysztof ORCID: 0000-0003-2236-7455, Rerkamnuaychoke, Budsaba, Rey Gonzalez, Danel, Robino, Carlo ORCID: 0000-0003-1187-7732, Roewer, Lutz ORCID: 0000-0001-9383-4941, Rosa, Alexandra ORCID: 0000-0002-1827-6828, Sajantila, Antti ORCID: 0000-0003-4117-5248, Sala, Andrea, Salvador, Jazelyn M., Sanz, Paula, Schmitt, Cornelia, Sharma, Anil K., Silva, Dayse A., Shin, Kyoung-Jin, Sijen, Titia, Sirker, Miriam ORCID: 0000-0003-2979-4257, Sivakova, Daniela, Skaro, Vedrana ORCID: 0000-0002-8275-867X, Solano-Matamoros, Carlos, Souto, Luis, Stenzl, Vlastimil, Sudoyo, Herawati, Syndercombe-Court, Denise, Tagliabracci, Adriano ORCID: 0000-0002-4434-0475, Taylor, Duncan ORCID: 0000-0003-0633-7424, Tillmar, Andreas, Tsybovsky, Iosif S., Tyler-Smith, Chris, van der Gaag, Kristiaan J., Vanek, Daniel, Volgyi, Antonia, Ward, Denise, Willemse, Patricia, Yap, Eric P. H., Yong, Rita Y. Y., Pajnic, Irena Zupanic and Kayser, Manfred (2014). Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats. Hum. Mutat., 35 (8). S. 1021 - 1033. HOBOKEN: WILEY. ISSN 1098-1004

Full text not available from this repository.

Abstract

Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RMY-STRs in identifying and separating unrelated and related males and provides a reference database. Published 2014 Wiley Periodicals, Inc.**

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ballantyne, Kaye N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ralf, ArwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aboukhalid, RachidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Achakzai, Niaz M.UNSPECIFIEDorcid.org/0000-0002-8872-6046UNSPECIFIED
Anjos, Maria J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ayub, QasimUNSPECIFIEDorcid.org/0000-0003-3291-0917UNSPECIFIED
Balazic, JozeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ballantyne, JackUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ballard, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, BurkhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bobillo, CeciliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bouabdellah, MehdiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burri, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capal, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caratti, StefanoUNSPECIFIEDorcid.org/0000-0002-8876-9724UNSPECIFIED
Cardenas, JorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cartault, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carvalho, Elizeu F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carvalho, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cheng, BaowenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coble, Michael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Comas, DavidUNSPECIFIEDorcid.org/0000-0002-5075-0956UNSPECIFIED
Corach, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Amato, Maria E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davison, SeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Knijff, PeterUNSPECIFIEDorcid.org/0000-0002-0899-771XUNSPECIFIED
De Ungria, Maria Corazon A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Decorte, RonnyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobosz, TadeuszUNSPECIFIEDorcid.org/0000-0003-0413-9109UNSPECIFIED
Dupuy, Berit M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elmrghni, SamirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gliwinski, MateuszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomes, Sara C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grol, LaurensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haas, CordulaUNSPECIFIEDorcid.org/0000-0001-8122-1427UNSPECIFIED
Hanson, ErinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henke, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henke, LotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrera-Rodriguez, FabiolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hill, Carolyn R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holmlund, GunillaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Honda, KatsuyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Immel, Uta-DorotheeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Inokuchi, ShotaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jobling, Mark A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaddura, MahmoudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, Jong S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, Soon H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, WookUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
King, Turi E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klausriegler, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kling, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kovacevic, LejlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kovatsi, LedaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krajewski, PawelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kravchenko, SergeyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larmuseau, Maarten H. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Eun YoungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lessig, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Livshits, Ludmila A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marjanovic, DamirUNSPECIFIEDorcid.org/0000-0002-7472-4525UNSPECIFIED
Minarik, MarekUNSPECIFIEDorcid.org/0000-0002-0615-6116UNSPECIFIED
Mizuno, NatsukoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moreira, HelenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morling, NielsUNSPECIFIEDorcid.org/0000-0002-9463-5087UNSPECIFIED
Mukherjee, MeetaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munier, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nagaraju, JavaregowdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhuber, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nie, ShengjieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nilasitsataporn, PremlaphatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nishi, TakekiUNSPECIFIEDorcid.org/0000-0002-6582-097XUNSPECIFIED
Oh, Hye H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olofsson, JillUNSPECIFIEDorcid.org/0000-0002-9527-6573UNSPECIFIED
Onofri, ValerioUNSPECIFIEDorcid.org/0000-0002-1294-1444UNSPECIFIED
Palo, Jukka U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pamjav, HorolmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parson, WaltherUNSPECIFIEDorcid.org/0000-0002-5692-2392UNSPECIFIED
Petlach, MichalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phillips, ChristopherUNSPECIFIEDorcid.org/0000-0002-9601-0128UNSPECIFIED
Ploski, RafalUNSPECIFIEDorcid.org/0000-0001-6286-5526UNSPECIFIED
Prasad, Samayamantri P. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Primorac, DraganUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Purnomo, Gludhug A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Purps, JosephineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rangel-Villalobos, HectorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rebala, KrzysztofUNSPECIFIEDorcid.org/0000-0003-2236-7455UNSPECIFIED
Rerkamnuaychoke, BudsabaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rey Gonzalez, DanelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robino, CarloUNSPECIFIEDorcid.org/0000-0003-1187-7732UNSPECIFIED
Roewer, LutzUNSPECIFIEDorcid.org/0000-0001-9383-4941UNSPECIFIED
Rosa, AlexandraUNSPECIFIEDorcid.org/0000-0002-1827-6828UNSPECIFIED
Sajantila, AnttiUNSPECIFIEDorcid.org/0000-0003-4117-5248UNSPECIFIED
Sala, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salvador, Jazelyn M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanz, PaulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitt, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharma, Anil K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silva, Dayse A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shin, Kyoung-JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sijen, TitiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sirker, MiriamUNSPECIFIEDorcid.org/0000-0003-2979-4257UNSPECIFIED
Sivakova, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skaro, VedranaUNSPECIFIEDorcid.org/0000-0002-8275-867XUNSPECIFIED
Solano-Matamoros, CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Souto, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stenzl, VlastimilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sudoyo, HerawatiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Syndercombe-Court, DeniseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tagliabracci, AdrianoUNSPECIFIEDorcid.org/0000-0002-4434-0475UNSPECIFIED
Taylor, DuncanUNSPECIFIEDorcid.org/0000-0003-0633-7424UNSPECIFIED
Tillmar, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsybovsky, Iosif S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tyler-Smith, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Gaag, Kristiaan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanek, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volgyi, AntoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ward, DeniseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willemse, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yap, Eric P. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yong, Rita Y. Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pajnic, Irena ZupanicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kayser, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-433313
DOI: 10.1002/humu.22599
Journal or Publication Title: Hum. Mutat.
Volume: 35
Number: 8
Page Range: S. 1021 - 1033
Date: 2014
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1098-1004
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STR HAPLOTYPES; RECOMMENDATIONS; HISTORY; ISFGMultiple languages
Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43331

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