Zander, Esther, Fernandez-Gonzalez, Ana, Schleicher, Xenia, Dammhayn, Cathrin, Kamolvit, Witchuda, Seifert, Harald and Higgins, Paul G. ORCID: 0000-0001-8677-9454 (2014). Worldwide dissemination of acquired carbapenem-hydrolysing class D beta-lactamases in Acinetobacter spp. other than Acinetobacter baumannii. Int. J. Antimicrob. Agents, 43 (4). S. 375 - 378. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-7913
Full text not available from this repository.Abstract
The aim of this study was to identify acquired OXA-type carbapenemases in Acinetobacter spp. other than Acinetobacter baumannii. From a total of 453 carbapenem-susceptible and -resistant Acinetobacter isolates collected worldwide, 23 were positive for bla(OXA) genes by multiplex PCR. These isolates were identified as Acinetobacter pittn (n=18), Acinetobacter nosocomialis (n=2), Acinetobacter junn (n=1) and Acinetobacter genomic species 14TU/13BJ (n=2). The blaoxA genes and associated insertion sequence (IS) elements were sequenced by primer walking. In 11 of these isolates, sequencing of the PCR products revealed that they were false-positive for bla(OXA). The remaining 12 isolates, originating from Europe, Asia, South America, North America and South Africa, harboured OXA-23 (n=4), OXA-58 (n=5), OXA-40-like (n=1) and OXA143-like (n=1); oneA. plan isolate harboured both OXA-23 and OXA-58. IS elements were associated with blaoxA in 10 isolates. OXA multiplex PCR showed a high degree of false-positive results (47.8%), indicating that detection of blaoxA in non-baumannn Acinetobacter spp. should be confirmed using additional methods. (C) 2014 Elsevier BY, and the International Society of Chemotherapy. All rights reserved.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-442295 | ||||||||||||||||||||||||||||||||
DOI: | 10.1016/j.ijantimicag.2014.01.012 | ||||||||||||||||||||||||||||||||
Journal or Publication Title: | Int. J. Antimicrob. Agents | ||||||||||||||||||||||||||||||||
Volume: | 43 | ||||||||||||||||||||||||||||||||
Number: | 4 | ||||||||||||||||||||||||||||||||
Page Range: | S. 375 - 378 | ||||||||||||||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||||||||||||||
Publisher: | ELSEVIER SCIENCE BV | ||||||||||||||||||||||||||||||||
Place of Publication: | AMSTERDAM | ||||||||||||||||||||||||||||||||
ISSN: | 1872-7913 | ||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/44229 |
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