Universität zu Köln

Szczepanowska, Karolina ORCID: 0000-0003-4689-2350 and Trifunovic, Aleksandra (2021). Tune instead of destroy: How proteolysis keeps OXPHOS in shape. Biochim. Biophys. Acta-Bioenerg., 1862 (4). AMSTERDAM: ELSEVIER. ISSN 1879-2650

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Abstract

Mitochondria are highly dynamic and stress-responsive organelles that are renewed, maintained and removed by a number of different mechanisms. Recent findings bring more evidence for the focused, defined, and regulatory function of the intramitochondrial proteases extending far beyond the traditional concepts of damage control and stress responses. Until recently, the macrodegradation processes, such as mitophagy, were promoted as the major regulator of OXPHOS remodelling and turnover. However, the spatiotemporal dynamics of the OXPHOS system can be greatly modulated by the intrinsic mitochondrial mechanisms acting apart from changes in the global mitochondrial dynamics. This, in turn, may substantially contribute to the shaping of the metabolic status of the cell.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Szczepanowska, Karolina UNSPECIFIED orcid.org/0000-0003-4689-2350 UNSPECIFIED Trifunovic, Aleksandra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-574410
DOI:	10.1016/j.bbabio.2020.148365
Journal or Publication Title:	Biochim. Biophys. Acta-Bioenerg.
Volume:	1862
Number:	4
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1879-2650
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biochemistry & Molecular Biology; Biophysics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57441