Universität zu Köln

Sujana, Chaterina ORCID: 0000-0002-0663-2557, Salomaa, Veikko ORCID: 0000-0001-7563-5324, Kee, Frank, Costanzo, Simona ORCID: 0000-0003-4569-1186, Soderberg, Stefan ORCID: 0000-0001-9225-1306, Jordan, Jens, Jousilahti, Pekka, Neville, Charlotte, Iacoviello, Licia ORCID: 0000-0003-0514-5885, Oskarsson, Viktor, Westermann, Dirk, Koenig, Wolfgang ORCID: 0000-0002-2064-9603, Kuulasmaa, Kari, Reinikainen, Jaakko, Blankenberg, Stefan, Zeller, Tanja, Herder, Christian, Mansmann, Ulrich, Peters, Annette ORCID: 0000-0001-6645-0985 and Thorand, Barbara (2021). Natriuretic Peptides and Risk of Type 2 Diabetes: Results From the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium. Diabetes Care, 44 (11). S. 2527 - 2536. ALEXANDRIA: AMER DIABETES ASSOC. ISSN 1935-5548

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Abstract

OBJECTIVE Natriuretic peptide (NP) concentrations are increased in cardiovascular diseases (CVDs) but are associated with a lower diabetes risk. We investigated associations of N-terminal pro-B-type NP (NT-proBNP) and midregional proatrial NP (MR-proANP) with incident type 2 diabetes stratified by the presence of CVD. RESEARCH DESIGN AND METHODS Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium, we included 45,477 participants with NT-proBNP measurements (1,707 developed type 2 diabetes over 6.5 years of median follow-up; among these, 209 had CVD at baseline) and 11,537 participants with MR-proANP measurements (857 developed type 2 diabetes over 13.8 years of median follow-up; among these, 106 had CVD at baseline). The associations were estimated using multivariable Cox regression models. RESULTS Both NPs were inversely associated with incident type 2 diabetes (hazard ratios [95% CI] per 1-SD increase of log NP: 0.84 [0.79; 0.89] for NT-proBNP and 0.77 [0.71; 0.83] for MR-proANP). The inverse association between NT-proBNP and type 2 diabetes was significant in individuals without CVD but not in individuals with CVD (0.81 [0.76; 0.86] vs. 1.04 [0.90; 1.19]; P multiplicative interaction = 0.001). There was no significant difference in the association of MR-proANP with type 2 diabetes between individuals without and with CVD (0.75 [0.69; 0.82] vs. 0.81 [0.66; 0.99]; P multiplicative interaction = 0.236). CONCLUSIONS NT-proBNP and MR-proANP are inversely associated with incident type 2 diabetes. However, the inverse association of NT-proBNP seems to be modified by the presence of CVD. Further investigations are warranted to confirm our findings and to investigate the underlying mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sujana, Chaterina UNSPECIFIED orcid.org/0000-0002-0663-2557 UNSPECIFIED Salomaa, Veikko UNSPECIFIED orcid.org/0000-0001-7563-5324 UNSPECIFIED Kee, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Costanzo, Simona UNSPECIFIED orcid.org/0000-0003-4569-1186 UNSPECIFIED Soderberg, Stefan UNSPECIFIED orcid.org/0000-0001-9225-1306 UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Jousilahti, Pekka UNSPECIFIED UNSPECIFIED UNSPECIFIED Neville, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Iacoviello, Licia UNSPECIFIED orcid.org/0000-0003-0514-5885 UNSPECIFIED Oskarsson, Viktor UNSPECIFIED UNSPECIFIED UNSPECIFIED Westermann, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Wolfgang UNSPECIFIED orcid.org/0000-0002-2064-9603 UNSPECIFIED Kuulasmaa, Kari UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinikainen, Jaakko UNSPECIFIED UNSPECIFIED UNSPECIFIED Blankenberg, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeller, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Herder, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mansmann, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Annette UNSPECIFIED orcid.org/0000-0001-6645-0985 UNSPECIFIED Thorand, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603909
DOI:	10.2337/dc21-0811
Journal or Publication Title:	Diabetes Care
Volume:	44
Number:	11
Page Range:	S. 2527 - 2536
Date:	2021
Publisher:	AMER DIABETES ASSOC
Place of Publication:	ALEXANDRIA
ISSN:	1935-5548
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEART-FAILURE; PREDICTS; OBESITY; ADULTS Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60390