Universität zu Köln

Hommen, Franziska ORCID: 0000-0002-1612-6973, Bilican, Saygin ORCID: 0000-0001-9448-6504 and Vilchez, David ORCID: 0000-0002-0801-0743 (2022). Protein clearance strategies for disease intervention. J. Neural Transm., 129 (2). S. 141 - 173. WIEN: SPRINGER WIEN. ISSN 1435-1463

Sarroca, Sara, Gatius, Alao, Rodriguez-Farre, Eduard ORCID: 0000-0001-9305-3168, Vilchez, David ORCID: 0000-0002-0801-0743, Pallas, Merce, Grinan-Ferre, Christian, Sanfeliu, Coral ORCID: 0000-0002-9004-1206 and Corpas, Ruben ORCID: 0000-0002-7051-1493 (2021). Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms. J. Nutr. Biochem., 89. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-4847

Koyuncu, Seda, Loureiro, Rute ORCID: 0000-0002-2023-2429, Lee, Hyun Ju, Wagle, Prerana, Krueger, Marcus and Vilchez, David ORCID: 0000-0002-0801-0743 (2021). Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Nature, 596 (7871). S. 285 - 317. BERLIN: NATURE PORTFOLIO. ISSN 1476-4687

Saez, Isabel, Gerbracht, Jennifer, V, Koyuncu, Seda, Lee, Hyun Ju, Horn, Moritz, Kroef, Virginia, Denzel, Martin S., Dieterich, Christoph, Gehring, Niels H. ORCID: 0000-0001-7792-1164 and Vilchez, David ORCID: 0000-0002-0801-0743 (2020). The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Lett., 594 (1). S. 175 - 189. HOBOKEN: WILEY. ISSN 1873-3468

Lee, Hyun Ju, Noormohammadi, Alireza, Koyuncu, Seda, Calculli, Giuseppe, Simic, Milos S., Herholz, Marija, Trifunovic, Aleksandra ORCID: 0000-0002-5472-3517 and Vilchez, David ORCID: 0000-0002-0801-0743 (2019). Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans. Nat. Metab., 1 (8). S. 790 - 811. LONDON: NATURE PUBLISHING GROUP. ISSN 2522-5812

Saez, Isabel, Koyuncu, Seda, Gutierrez-Garcia, Ricardo, Dieterich, Christoph and Vilchez, David ORCID: 0000-0002-0801-0743 (2018). Insights into the ubiquitin-proteasome system of human embryonic stem cells. Sci Rep, 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

Irmak, Dilber, Fatima, Azra, Gutierrez-Garcia, Ricardo, Rinschen, Markus M., Wagle, Prerana, Altmueller, Janine, Arrigoni, Laura, Hummel, Barbara ORCID: 0000-0001-6563-3675, Klein, Corinna, Frese, Christian K., Sawarkar, Ritwick, Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 and Vilchez, David ORCID: 0000-0002-0801-0743 (2018). Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations. Hum. Mol. Genet., 27 (23). S. 4117 - 4135. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2083

Noormohammadi, Alireza, Calculli, Giuseppe, Gutierrez-Garcia, Ricardo, Khodakarami, Amirabbas, Koyuncu, Seda and Vilchez, David ORCID: 0000-0002-0801-0743 (2018). Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells. Cell. Mol. Life Sci., 75 (2). S. 275 - 291. BASEL: SPRINGER BASEL AG. ISSN 1420-9071

Goncalves, Ines do Carmo G., Brecht, Johanna, Thelen, Maximilian P., Rehorst, Wiebke A., Peters, Miriam, Lee, Hyun Ju, Motameny, Susanne, Torres-Benito, Laura, Ebrahimi-Fakhari, Darius ORCID: 0000-0002-0026-4714, Kononenko, Natalia L., Altmueller, Janine, Vilchez, David ORCID: 0000-0002-0801-0743, Sahin, Mustafa, Wirth, Brunhilde ORCID: 0000-0003-4051-5191 and Kye, Min Jeong ORCID: 0000-0002-1323-7256 (2018). Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Sci Rep, 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

Koyuncu, Seda, Saez, Isabel, Lee, Hyun Ju, Gutierrez-Garcia, Ricardo, Pokrzywa, Wojciech ORCID: 0000-0002-5110-4462, Fatima, Azra, Hoppe, Thorsten ORCID: 0000-0002-4734-9352 and Vilchez, David ORCID: 0000-0002-0801-0743 (2018). The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat. Commun., 9. BERLIN: NATURE RESEARCH. ISSN 2041-1723

Lee, Hyun Ju, Gutierrez-Garcia, Ricardo and Vilchez, David ORCID: 0000-0002-0801-0743 (2017). Embryonic stem cells: a novel paradigm to study proteostasis? FEBS J., 284 (3). S. 391 - 399. HOBOKEN: WILEY-BLACKWELL. ISSN 1742-4658

Koyuncu, Seda, Fatima, Azra, Gutierrez-Garcia, Ricardo and Vilchez, David ORCID: 0000-0002-0801-0743 (2017). Proteostasis of Huntingtin in Health and Disease. Int. J. Mol. Sci., 18 (7). BASEL: MDPI. ISSN 1422-0067

Lee, Hyun Ju, Bartsch, Deniz, Xiao, Cally ORCID: 0000-0001-7172-3175, Guerrero, Santiago ORCID: 0000-0003-3473-7214, Ahuja, Gaurav ORCID: 0000-0002-2837-9361, Schindler, Christina, Moresco, James J., Yates, John R., III, Gebauer, Fatima ORCID: 0000-0001-7563-0013, Bazzi, Hisham ORCID: 0000-0001-8388-4005, Dieterich, Christoph, Kurian, Leo ORCID: 0000-0001-7466-5169 and Vilchez, David ORCID: 0000-0002-0801-0743 (2017). A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells. Nat. Commun., 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Noormohammadi, Alireza, Khodakarami, Amirabbas, Gutierrez-Garcia, Ricardo, Lee, Hyun Ju, Koyuncu, Seda, Nig, Tim Ko, Schindler, Christina, Saez, Isabel, Fatima, Azra, Dieterich, Christoph and Vilchez, David ORCID: 0000-0002-0801-0743 (2016). Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C-elegans lifespan. Nat. Commun., 7. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Rinschen, Markus M., Bharill, Puneet, Wu, Xiongwu, Kohli, Priyanka ORCID: 0000-0002-0651-4008, Reinert, Matthaeus J., Kretz, Oliver, Saez, Isabel, Schermer, Bernhard ORCID: 0000-0002-5194-9000, Hoehne, Martin, Bartram, Malte P., Aravamudhan, Sriram, Brooks, Bernard R., Vilchez, David ORCID: 0000-0002-0801-0743, Huber, Tobias B. ORCID: 0000-0001-7175-5062, Mueller, Roman-Ulrich, Krueger, Marcus ORCID: 0000-0003-2008-4582 and Benzing, Thomas (2016). The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum. Mol. Genet., 25 (7). S. 1328 - 1345. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2083

Koyuncu, Seda, Irmak, Dither, Saez, Isabel and Vilchez, David ORCID: 0000-0002-0801-0743 (2015). Defining the General Principles of Stem Cell Aging: Lessons from Organismal Models. Curr. Stem. Cell Rep., 1 (3). S. 162 - 170. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2198-7866

Khodakarami, Amirabbas, Saez, Isabel, Mels, Johanna and Vilchez, David ORCID: 0000-0002-0801-0743 (2015). Mediation of organismal aging and somatic proteostasis by the germline. Front. Mol. Biosci., 2. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-889X

Saez, Isabel and Vilchez, David ORCID: 0000-0002-0801-0743 (2015). Protein clearance mechanisms and their demise in age-related neurodegenerative diseases. AIMS Mol. Sci., 2 (1). S. 1 - 22. SPRINGFIELD: AMER INST MATHEMATICAL SCIENCES-AIMS. ISSN 2372-0301

Saez, Isabel and Vilchez, David ORCID: 0000-0002-0801-0743 (2014). The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases. Curr. Genomics, 15 (1). S. 38 - 52. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1875-5488

Vilchez, David ORCID: 0000-0002-0801-0743, Simic, Milos S. and Dillin, Andrew (2014). Proteostasis and aging of stem cells. Trends Cell Biol., 24 (3). S. 161 - 171. LONDON: ELSEVIER SCIENCE LONDON. ISSN 0962-8924

Vilchez, David ORCID: 0000-0002-0801-0743, Saez, Isabel and Dillin, Andrew (2014). The role of protein clearance mechanisms in organismal ageing and age-related diseases. Nat. Commun., 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723