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2022
Balaji, Vishnu, Mueller, Leonie, Lorenz, Robin, Kevei, Eva ORCID: 0000-0002-0560-9208, Zhang, William H., Santiago, Ulises, Gebauer, Jan
ORCID: 0000-0002-3989-4748, Llamas, Ernesto, Vilchez, David, Camacho, Carlos J., Pokrzywa, Wojciech and Hoppe, Thorsten
(2022).
A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing.
Mol. Cell, 82 (17).
S. 3239 - 3267.
CAMBRIDGE:
CELL PRESS.
ISSN 1097-4164
Hommen, Franziska ORCID: 0000-0002-1612-6973, Bilican, Saygin
ORCID: 0000-0001-9448-6504 and Vilchez, David
ORCID: 0000-0002-0801-0743
(2022).
Protein clearance strategies for disease intervention.
J. Neural Transm., 129 (2).
S. 141 - 173.
WIEN:
SPRINGER WIEN.
ISSN 1435-1463
2021
Koyuncu, Seda, Loureiro, Rute ORCID: 0000-0002-2023-2429, Lee, Hyun Ju, Wagle, Prerana, Krueger, Marcus and Vilchez, David
ORCID: 0000-0002-0801-0743
(2021).
Rewiring of the ubiquitinated proteome determines ageing in C. elegans.
Nature, 596 (7871).
S. 285 - 317.
BERLIN:
NATURE PORTFOLIO.
ISSN 1476-4687
Llamas, Ernesto ORCID: 0000-0001-9262-2402, Torres-Montilla, Salvador, Lee, Hyun Ju, Barja, Maria Victoria, Schlimgen, Elena, Dunken, Nick
ORCID: 0000-0003-0563-307X, Wagle, Prerana, Werr, Wolfgang, Zuccaro, Alga
ORCID: 0000-0002-8026-0114, Rodriguez-Concepcion, Manuel and Vilchez, David
(2021).
The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress.
Aging Cell, 20 (8).
HOBOKEN:
WILEY.
ISSN 1474-9726
Sarroca, Sara, Gatius, Alao, Rodriguez-Farre, Eduard ORCID: 0000-0001-9305-3168, Vilchez, David
ORCID: 0000-0002-0801-0743, Pallas, Merce, Grinan-Ferre, Christian, Sanfeliu, Coral
ORCID: 0000-0002-9004-1206 and Corpas, Ruben
ORCID: 0000-0002-7051-1493
(2021).
Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms.
J. Nutr. Biochem., 89.
NEW YORK:
ELSEVIER SCIENCE INC.
ISSN 1873-4847
2020
Fatima, Azra, Irmak, Dilber, Noormohammadi, Alireza, Rinschen, Markus M., Das, Aniruddha ORCID: 0000-0002-7704-3573, Leidecker, Orsolya, Schindler, Christina, Sanchez-Gaya, Victor, Wagle, Prerana, Pokrzywa, Wojciech
ORCID: 0000-0002-5110-4462, Hoppe, Thorsten
ORCID: 0000-0002-4734-9352, Rada-Iglesias, Alvaro and Vilchez, David
(2020).
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.
Commun. Biol., 3 (1).
NEW YORK:
NATURE PUBLISHING GROUP.
ISSN 2399-3642
Llamas, Ernesto, Alirzayeva, Hafiza, Loureiro, Rute and Vilchez, David (2020). The intrinsic proteostasis network of stem cells. Curr. Opin. Cell Biol., 67. S. 46 - 56. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410
Saez, Isabel, Gerbracht, Jennifer, V, Koyuncu, Seda, Lee, Hyun Ju, Horn, Moritz, Kroef, Virginia, Denzel, Martin S., Dieterich, Christoph, Gehring, Niels H. ORCID: 0000-0001-7792-1164 and Vilchez, David
ORCID: 0000-0002-0801-0743
(2020).
The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.
FEBS Lett., 594 (1).
S. 175 - 189.
HOBOKEN:
WILEY.
ISSN 1873-3468
Thiruvalluvan, Arun, de Mattos, Eduardo P., Brunsting, Jeanette F., Bakels, Rob, Serlidaki, Despina, Barazzuol, Lara, Conforti, Paola, Fatima, Azra, Koyuncu, Seda, Cattaneo, Elena, Vilchez, David, Bergink, Steven, Boddeke, Erik H. W. G., Copray, Sjef and Kampinga, Harm H. (2020). DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis. Mol. Cell, 78 (2). S. 346 - 368. CAMBRIDGE: CELL PRESS. ISSN 1097-4164
2019
Kumsta, Caroline, Chang, Jessica T., Lee, Reina, Tan, Ee Phie, Yang, Yongzhi, Loureiro, Rute, Choy, Elizabeth H., Lim, Shaun H. Y., Saez, Isabel, Springhorn, Alexander, Hoppe, Thorsten ORCID: 0000-0002-4734-9352, Vilchez, David and Hansen, Malene
(2019).
The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
Nat. Commun., 10.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Lee, Hyun Ju, Noormohammadi, Alireza, Koyuncu, Seda, Calculli, Giuseppe, Simic, Milos S., Herholz, Marija, Trifunovic, Aleksandra ORCID: 0000-0002-5472-3517 and Vilchez, David
ORCID: 0000-0002-0801-0743
(2019).
Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans.
Nat. Metab., 1 (8).
S. 790 - 811.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2522-5812
2018
Goncalves, Ines do Carmo G., Brecht, Johanna, Thelen, Maximilian P., Rehorst, Wiebke A., Peters, Miriam, Lee, Hyun Ju, Motameny, Susanne, Torres-Benito, Laura, Ebrahimi-Fakhari, Darius ORCID: 0000-0002-0026-4714, Kononenko, Natalia L., Altmueller, Janine, Vilchez, David
ORCID: 0000-0002-0801-0743, Sahin, Mustafa, Wirth, Brunhilde
ORCID: 0000-0003-4051-5191 and Kye, Min Jeong
ORCID: 0000-0002-1323-7256
(2018).
Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy.
Sci Rep, 8.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2045-2322
Goncalves, Ines do Carmo G., Brecht, Johanna, Thelen, Maximilian P., Rehorst, Wiebke A., Peters, Miriam, Lee, Hyun Ju, Motameny, Susanne, Torres-Benito, Laura, Ebrahimi-Fakhari, Darius ORCID: 0000-0002-0026-4714, Kononenko, Natalia L., Altmueller, Janine, Vilchez, David, Sahin, Mustafa, Wirth, Brunhilde and Kye, Min Jeong
(2018).
Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy (vol 8, 7907, 2018).
Sci Rep, 8.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2045-2322
Irmak, Dilber, Fatima, Azra, Gutierrez-Garcia, Ricardo, Rinschen, Markus M., Wagle, Prerana, Altmueller, Janine, Arrigoni, Laura, Hummel, Barbara ORCID: 0000-0001-6563-3675, Klein, Corinna, Frese, Christian K., Sawarkar, Ritwick, Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341 and Vilchez, David
ORCID: 0000-0002-0801-0743
(2018).
Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.
Hum. Mol. Genet., 27 (23).
S. 4117 - 4135.
OXFORD:
OXFORD UNIV PRESS.
ISSN 1460-2083
Koyuncu, Seda, Saez, Isabel, Lee, Hyun Ju, Gutierrez-Garcia, Ricardo, Pokrzywa, Wojciech ORCID: 0000-0002-5110-4462, Fatima, Azra, Hoppe, Thorsten
ORCID: 0000-0002-4734-9352 and Vilchez, David
ORCID: 0000-0002-0801-0743
(2018).
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients.
Nat. Commun., 9.
BERLIN:
NATURE RESEARCH.
ISSN 2041-1723
Noormohammadi, Alireza, Calculli, Giuseppe, Gutierrez-Garcia, Ricardo, Khodakarami, Amirabbas, Koyuncu, Seda and Vilchez, David ORCID: 0000-0002-0801-0743
(2018).
Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells.
Cell. Mol. Life Sci., 75 (2).
S. 275 - 291.
BASEL:
SPRINGER BASEL AG.
ISSN 1420-9071
Saez, Isabel, Koyuncu, Seda, Gutierrez-Garcia, Ricardo, Dieterich, Christoph and Vilchez, David ORCID: 0000-0002-0801-0743
(2018).
Insights into the ubiquitin-proteasome system of human embryonic stem cells.
Sci Rep, 8.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2045-2322
2017
Koyuncu, Seda, Fatima, Azra, Gutierrez-Garcia, Ricardo and Vilchez, David ORCID: 0000-0002-0801-0743
(2017).
Proteostasis of Huntingtin in Health and Disease.
Int. J. Mol. Sci., 18 (7).
BASEL:
MDPI.
ISSN 1422-0067
Lee, Hyun Ju, Bartsch, Deniz, Xiao, Cally ORCID: 0000-0001-7172-3175, Guerrero, Santiago
ORCID: 0000-0003-3473-7214, Ahuja, Gaurav
ORCID: 0000-0002-2837-9361, Schindler, Christina, Moresco, James J., Yates, John R., III, Gebauer, Fatima
ORCID: 0000-0001-7563-0013, Bazzi, Hisham
ORCID: 0000-0001-8388-4005, Dieterich, Christoph, Kurian, Leo
ORCID: 0000-0001-7466-5169 and Vilchez, David
ORCID: 0000-0002-0801-0743
(2017).
A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells.
Nat. Commun., 8.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Lee, Hyun Ju, Gutierrez-Garcia, Ricardo and Vilchez, David ORCID: 0000-0002-0801-0743
(2017).
Embryonic stem cells: a novel paradigm to study proteostasis?
FEBS J., 284 (3).
S. 391 - 399.
HOBOKEN:
WILEY-BLACKWELL.
ISSN 1742-4658
2016
Noormohammadi, Alireza, Khodakarami, Amirabbas, Gutierrez-Garcia, Ricardo, Lee, Hyun Ju, Koyuncu, Seda, Nig, Tim Ko, Schindler, Christina, Saez, Isabel, Fatima, Azra, Dieterich, Christoph and Vilchez, David ORCID: 0000-0002-0801-0743
(2016).
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C-elegans lifespan.
Nat. Commun., 7.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Rinschen, Markus M., Bharill, Puneet, Wu, Xiongwu, Kohli, Priyanka ORCID: 0000-0002-0651-4008, Reinert, Matthaeus J., Kretz, Oliver, Saez, Isabel, Schermer, Bernhard
ORCID: 0000-0002-5194-9000, Hoehne, Martin, Bartram, Malte P., Aravamudhan, Sriram, Brooks, Bernard R., Vilchez, David
ORCID: 0000-0002-0801-0743, Huber, Tobias B.
ORCID: 0000-0001-7175-5062, Mueller, Roman-Ulrich, Krueger, Marcus
ORCID: 0000-0003-2008-4582 and Benzing, Thomas
(2016).
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
Hum. Mol. Genet., 25 (7).
S. 1328 - 1345.
OXFORD:
OXFORD UNIV PRESS.
ISSN 1460-2083
2015
Khodakarami, Amirabbas, Saez, Isabel, Mels, Johanna and Vilchez, David ORCID: 0000-0002-0801-0743
(2015).
Mediation of organismal aging and somatic proteostasis by the germline.
Front. Mol. Biosci., 2.
LAUSANNE:
FRONTIERS MEDIA SA.
ISSN 2296-889X
Koyuncu, Seda, Irmak, Dither, Saez, Isabel and Vilchez, David ORCID: 0000-0002-0801-0743
(2015).
Defining the General Principles of Stem Cell Aging: Lessons from Organismal Models.
Curr. Stem. Cell Rep., 1 (3).
S. 162 - 170.
HEIDELBERG:
SPRINGER HEIDELBERG.
ISSN 2198-7866
Saez, Isabel and Vilchez, David ORCID: 0000-0002-0801-0743
(2015).
Protein clearance mechanisms and their demise in age-related neurodegenerative diseases.
AIMS Mol. Sci., 2 (1).
S. 1 - 22.
SPRINGFIELD:
AMER INST MATHEMATICAL SCIENCES-AIMS.
ISSN 2372-0301
2014
Saez, Isabel and Vilchez, David ORCID: 0000-0002-0801-0743
(2014).
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases.
Curr. Genomics, 15 (1).
S. 38 - 52.
SHARJAH:
BENTHAM SCIENCE PUBL LTD.
ISSN 1875-5488
Vilchez, David ORCID: 0000-0002-0801-0743, Saez, Isabel and Dillin, Andrew
(2014).
The role of protein clearance mechanisms in organismal ageing and age-related diseases.
Nat. Commun., 5.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Vilchez, David ORCID: 0000-0002-0801-0743, Simic, Milos S. and Dillin, Andrew
(2014).
Proteostasis and aging of stem cells.
Trends Cell Biol., 24 (3).
S. 161 - 171.
LONDON:
ELSEVIER SCIENCE LONDON.
ISSN 0962-8924